A novel synthesis of 1-aryl-3-piperidone derivatives

Yinan Zhang, Richard B. Silverman*

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A novel method to construct the 1-aryl-3-piperidone scaffold is described here. Starting from 3,5-dichloroaniline, a seven-step synthesis, without the use of protecting groups, generates the desired 3-piperidone ring in an overall yield of 30% through a key Morita-Baylis-Hillman reaction and ring-closing metathesis, providing easy access to diverse and useful heterocycles.

Original languageEnglish (US)
Pages (from-to)573-575
Number of pages3
JournalTetrahedron Letters
Volume54
Issue number6
DOIs
StatePublished - Feb 6 2013

Keywords

  • 3-Piperidone
  • Heterocycles
  • Morita-Baylis-Hillman
  • Ring-closing metathesis
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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