Real-time 3D echocardiography (RT3DE) allows noninvasive evaluation of mitral annular 3D geometry. In this study, we propose a novel computerized method for the assessment of mitral annular (MA) geometry and analysis of MA motion through the cardiac cycle. We applied this technique to examine differences between normal subjects and patients with ischemic mitral regurgitation (IMR). The algorithm was evaluated using five saddle-shaped MA phantoms and then applied to both normal subjects and patients with IMR. Strong agreement between the estimated and actual angle of the MA phantoms was observed (y=0.99x+1.5, r=0.87, p<0.001, mean difference 2.66±10.9). In the clinical study, non-planarity angle at end-systole (ES) was significantly greater in IMR vs normal subjects (135±9.2 vs. 129.3±3.1, p<0.03). In all cases, MA was less planar at ES than ED. In IMR, MA was dilated (943±83 vs. 769±34 mm2, p<0.005) and motion of posterolateral MA was significantly reduced (7.3±1.3 vs 16.0±1.1 mm p<0.001). This approach can determine unique 3D descriptors of MA geometry that may provide information about pathophysiologic changes in patients with IMR.
ASJC Scopus subject areas
- Computer Science Applications
- Cardiology and Cardiovascular Medicine