A novel technique for endovascular detection and removal of radiographic contrast during angiography

Hyeonsoo Chang, Ali H.M. Hassan, Young L. Kim, Lester J. Lloyd, Bon Kwon Koo, Junya Ako, Yasuhiro Honda, Charles J. Davidson, Peter J. Fitzgerald

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


OBJECTIVES: This study aims at in-vitro validation of the principles of endovascular detection of contrast medium and assessing the feasibility of in-vivo detection and removal of contrast during angiography. BACKGROUND: Contrast-induced nephropathy is a growing concern in current percutaneous interventions with increasing lesion complexity and patient comorbidity. To address this clinical problem, a novel method of endovascular detection and automatic removal of contrast has been developed, and is comprised of a catheter-based system with a reflectance-type optical sensor. METHODS: Blood samples were obtained from ovine subjects to characterize the optical response of blood by measuring the reflectance spectrum at varying levels of hematocrit diluted by a contrast agent. The results from the in-vitro test were implemented into an in-vivo system. An aspiration catheter equipped with a fiberoptic sensor was inserted into the coronary sinus (CS) of 5 canines. Contrast was administered through the coronary artery and reflectance signals were recorded at the CS. The removal rate was analyzed through 20 specimen collections. RESULTS: A proportional relationship was found between hematocrit and reflectance intensity in in-vitro test. Upon in-vivo detection of contrast, the sensor signal showed a 79.5 ± 9.9% (n ≤ 33) drop from the pre-injection baseline. This was highly reproducible and beyond the noise level of baseline, (2.5 ± 0.9%), enabling automatic activation of the aspiration system. The signal duration was 12.2 ± 3.7 seconds. The removal rate of contrast was 59.3 ± 11%. CONCLUSION: The present study validated the principles of endovascular contrast detection and demonstrated the feasibility of an in-vivo, catheter-based removal of contrast using reflectance technology.

Original languageEnglish (US)
Pages (from-to)314-318
Number of pages5
JournalJournal of Invasive Cardiology
Issue number7
StatePublished - Jul 2009


  • Contrast detection
  • Contrast-induced nephropathy
  • Intravascular optic sensor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'A novel technique for endovascular detection and removal of radiographic contrast during angiography'. Together they form a unique fingerprint.

Cite this