A novel tool to analyze MRI recurrence patterns in glioblastoma

Wolfgang Wick*, Roger Stupp, Anna Carina Beule, Jacoline Bromberg, Antje Wick, Ulrike Ernemann, Michael Platten, Christine Marosi, Warren P. Mason, Martin Van Den Bent, Michael Weller, Chris Rorden, Hans Otto Karnath

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


At least 10% of glioblastoma relapses occur at distant and even contralateral locations. This disseminated growth limits surgical intervention and contributes to neurological morbidity. Preclinical data pointed toward a role for temozolomide (TMZ) in reducing radiotherapy-induced glioma cell invasiveness. Our objective was to develop and validate a new analysis tool of MRI data to examine the clinical recurrence pattern of glioblastomas. MRI-cro software was used to map the location and extent of initial preoperative and recurrent tumors on MRI of 63 patients in the European Organisation for Research and Treatment of Cancer (EORTC) 26981/22981/National Cancer Institute of Canada (NCIC) CE.3 study into the same stereotaxic space. This allowed us to examine changes of site and distance between the initial and the recurrent tumor on the group level. Thirty of the 63 patients were treated using radiotherapy, while the other patients completed a radiotherapy-plus-TMZ treatment. Baseline characteristics (median age, KPS) and outcome data (progression-free survival, overall survival) of the patients included in this analysis resemble those of the general study cohort. The patient groups did not differ in the promoter methylation status of methyl guanine methyltransferase (MGMT). Overall frequency of distant recurrences was 20%. Analysis of recurrence patterns revealed no difference between the groups in the size of the recurrent tumor or in the differential effect on the distance of the recurrences from the pre-operative tumor location. The data show the feasibility of groupwise recurrence pattern analysis. An effect of TMZ treatment on the recurrence pattern in the EORTC 26981/22981/NCIC CE.3 study could not be demonstrated.

Original languageEnglish (US)
Pages (from-to)1019-1024
Number of pages6
Issue number6
StatePublished - Dec 2008


  • Brain tumor
  • Invasiveness
  • MRIcro
  • Relapse pattern
  • Temozolomide

ASJC Scopus subject areas

  • Clinical Neurology
  • Oncology
  • Cancer Research


Dive into the research topics of 'A novel tool to analyze MRI recurrence patterns in glioblastoma'. Together they form a unique fingerprint.

Cite this