A nuclear strike against Listeria - The evolving life of LXR

Grant D. Barish, Ronald M. Evans*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


LXRs are members of the nuclear receptor superfamily and function as master regulators of cholesterol metabolism. In the macrophage, they control cholesterol efflux and inhibit the transcription factor NF-κB-mediated proinflammatory responses. In this issue of Cell, Joseph et al. (2004) discover surprising, protective functions for LXRα in innate immunity.

Original languageEnglish (US)
Pages (from-to)149-151
Number of pages3
Issue number2
StatePublished - Oct 15 2004

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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