LXRs are members of the nuclear receptor superfamily and function as master regulators of cholesterol metabolism. In the macrophage, they control cholesterol efflux and inhibit the transcription factor NF-κB-mediated proinflammatory responses. In this issue of Cell, Joseph et al. (2004) discover surprising, protective functions for LXRα in innate immunity.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)