A p53 polymorphism modifies the risk of hepatocellular carcinoma among non-carriers but not carriers of chronic hepatitis B virus infection

Zhong Zheng Zhu, Wen Ming Cong*, Shu Fang Liu, Zhi Hong Xian, Wei Qing Wu, Meng Chao Wu, Bin Gao, Li Fang Hou, Guan Shan Zhu

*Corresponding author for this work

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

To clarify the modifying effect of the codon 72 p53 polymorphism on hepatocellular carcinoma (HCC) stratified by chronic hepatitis B virus (HBV) infection status, 111 incident cases of HCC and 424 controls in HBV-negative subjects and 135 cases and 125 controls in HBV-positive subjects were identified. No correlation between the polymorphism and HCC risk was found when comparing the HBV-positive cases to controls. However, in HBV-negative subjects, Arg/Pro and Pro/Pro genotypes had a 1.97-fold and a 3.36-fold increased risk for HCC, respectively. In subjects with the Pro allele and family history of HCC yielded an 11.81-fold increased risk of HCC.

Original languageEnglish (US)
Pages (from-to)77-83
Number of pages7
JournalCancer Letters
Volume229
Issue number1
DOIs
StatePublished - Nov 8 2005

Keywords

  • DNA polymorphisms
  • Hepatitis B virus
  • Hepatocellular carcinoma
  • p53

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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