A pilot study: Comparing a novel noninvasive measure of cerebrovascular stability index with an invasive measure of cerebral autoregulation in neonates with congenital heart disease

Carlin A. Merkel; Kenneth M. Brady; Jodie K. Votava-Smith; Nhu N. Tran

doi:10.1017/cts.2023.581

A pilot study: Comparing a novel noninvasive measure of cerebrovascular stability index with an invasive measure of cerebral autoregulation in neonates with congenital heart disease

Carlin A. Merkel^*, Kenneth M. Brady, Jodie K. Votava-Smith, Nhu N. Tran

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Infants with congenital heart disease (CHD) may have impaired cerebral autoregulation (CA) associated with cerebral fractional tissue oxygen extraction (FTOE). We conducted a pilot study in nine CHD neonates to validate a noninvasive CA measure, cerebrovascular stability index (CSI), by eliciting responses to postural tilts. We compared CSI to an invasive measure of CA and to FTOE collected during tilts (FTOESpot). FTOESpot correlated with CSI, as did the change in FTOE during tilts, but CSI's correlation with impaired CA did not reach significance. Larger trials are indicated to validate CSI, allowing for noninvasive CA measurements and measurements in outpatient settings.

Original language	English (US)
Article number	e165
Journal	Journal of Clinical and Translational Science
Volume	7
Issue number	1
DOIs	https://doi.org/10.1017/cts.2023.581
State	Published - Jul 10 2023

Keywords

Cerebral autoregulation
cerebrovascular stability index
congenital heart disease
fractional tissue oxygen extraction
neonates

ASJC Scopus subject areas

General Medicine

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10.1017/cts.2023.581

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title = "A pilot study: Comparing a novel noninvasive measure of cerebrovascular stability index with an invasive measure of cerebral autoregulation in neonates with congenital heart disease",

abstract = "Infants with congenital heart disease (CHD) may have impaired cerebral autoregulation (CA) associated with cerebral fractional tissue oxygen extraction (FTOE). We conducted a pilot study in nine CHD neonates to validate a noninvasive CA measure, cerebrovascular stability index (CSI), by eliciting responses to postural tilts. We compared CSI to an invasive measure of CA and to FTOE collected during tilts (FTOESpot). FTOESpot correlated with CSI, as did the change in FTOE during tilts, but CSI's correlation with impaired CA did not reach significance. Larger trials are indicated to validate CSI, allowing for noninvasive CA measurements and measurements in outpatient settings.",

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author = "Merkel, {Carlin A.} and Brady, {Kenneth M.} and Votava-Smith, {Jodie K.} and Tran, {Nhu N.}",

note = "Publisher Copyright: {\textcopyright} The Author(s), 2023. Published by Cambridge University Press on behalf of The Association for Clinical and Translational Science.",

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language = "English (US)",

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A pilot study: Comparing a novel noninvasive measure of cerebrovascular stability index with an invasive measure of cerebral autoregulation in neonates with congenital heart disease. / Merkel, Carlin A.; Brady, Kenneth M.; Votava-Smith, Jodie K. et al.
In: Journal of Clinical and Translational Science, Vol. 7, No. 1, e165, 10.07.2023.

Research output: Contribution to journal › Article › peer-review

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T1 - A pilot study

T2 - Comparing a novel noninvasive measure of cerebrovascular stability index with an invasive measure of cerebral autoregulation in neonates with congenital heart disease

AU - Merkel, Carlin A.

AU - Brady, Kenneth M.

AU - Votava-Smith, Jodie K.

AU - Tran, Nhu N.

N1 - Publisher Copyright: © The Author(s), 2023. Published by Cambridge University Press on behalf of The Association for Clinical and Translational Science.

PY - 2023/7/10

Y1 - 2023/7/10

N2 - Infants with congenital heart disease (CHD) may have impaired cerebral autoregulation (CA) associated with cerebral fractional tissue oxygen extraction (FTOE). We conducted a pilot study in nine CHD neonates to validate a noninvasive CA measure, cerebrovascular stability index (CSI), by eliciting responses to postural tilts. We compared CSI to an invasive measure of CA and to FTOE collected during tilts (FTOESpot). FTOESpot correlated with CSI, as did the change in FTOE during tilts, but CSI's correlation with impaired CA did not reach significance. Larger trials are indicated to validate CSI, allowing for noninvasive CA measurements and measurements in outpatient settings.

AB - Infants with congenital heart disease (CHD) may have impaired cerebral autoregulation (CA) associated with cerebral fractional tissue oxygen extraction (FTOE). We conducted a pilot study in nine CHD neonates to validate a noninvasive CA measure, cerebrovascular stability index (CSI), by eliciting responses to postural tilts. We compared CSI to an invasive measure of CA and to FTOE collected during tilts (FTOESpot). FTOESpot correlated with CSI, as did the change in FTOE during tilts, but CSI's correlation with impaired CA did not reach significance. Larger trials are indicated to validate CSI, allowing for noninvasive CA measurements and measurements in outpatient settings.

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KW - cerebrovascular stability index

KW - congenital heart disease

KW - fractional tissue oxygen extraction

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A pilot study: Comparing a novel noninvasive measure of cerebrovascular stability index with an invasive measure of cerebral autoregulation in neonates with congenital heart disease

Abstract

Keywords

ASJC Scopus subject areas

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