TY - JOUR
T1 - A pilot study comparing the effect of flaxseed, aromatase inhibitor, and the combination on breast tumor biomarkers
AU - McCann, Susan E.
AU - Edge, Stephen B.
AU - Hicks, David G.
AU - Thompson, Lilian U.
AU - Morrison, Carl D.
AU - Fetterly, Gerald
AU - Andrews, Christopher
AU - Clark, Kim
AU - Wilton, John
AU - Kulkarni, Swati
N1 - Funding Information:
This article was supported by 1R21AT004024-01from NIH National Center for Complementary and Alternative Medicine; the Pathology Resource Network is a Roswell Park Cancer Center Support Grant shared resource, supported by NIH National Cancer Institute P30CA016056-32. Registered with clin-icaltrials.gov, NCT00612560, http://clinicaltrials.gov/ct2/show/ NCT00612560?term=flaxseed±and±aromatase&rank=1
PY - 2014/5/19
Y1 - 2014/5/19
N2 - Use of complementary approaches is common among breast cancer survivors. Potential interactions between aromatase inhibitors (AI) and high phytoestrogen foods, such as flaxseed (FS), are not often described. We conducted a pilot 2 × 2 factorial, randomized intervention study between tumor biopsy and resection, in 24 postmenopausal women with estrogen receptor positive (ER+) breast cancer, to assess the effects of FS and anastrozole, and possible interactions between them, on serum steroid hormone and tumor-related characteristics associated with long-term survival (Roswell Park Cancer Institute, 2007-2010). The effect of each treatment vs. placebo on outcomes was determined by linear regression adjusting for pretreatment measure, stage, and grade. Although not statistically significant, mean ERβ expression was approximately 40% lower from pre- to postintervention in the FS + AI group only. We observed a statistically significant negative association (β ± SE -0.3 ± 0.1; P = 0.03) for androstenedione in the FS + AI group vs. placebo and for DHEA with AI treatment (β ± SE -1.6 ± 0.6; P = 0.009). Enterolactone excretion was much lower in the FS + AI group compared to the FS group. Our results do not support strong effects of FS on AI activity for selected breast tumor characteristics or serum steroid hormone levels but suggest AI therapy might reduce the production of circulating mammalian lignans from FS.
AB - Use of complementary approaches is common among breast cancer survivors. Potential interactions between aromatase inhibitors (AI) and high phytoestrogen foods, such as flaxseed (FS), are not often described. We conducted a pilot 2 × 2 factorial, randomized intervention study between tumor biopsy and resection, in 24 postmenopausal women with estrogen receptor positive (ER+) breast cancer, to assess the effects of FS and anastrozole, and possible interactions between them, on serum steroid hormone and tumor-related characteristics associated with long-term survival (Roswell Park Cancer Institute, 2007-2010). The effect of each treatment vs. placebo on outcomes was determined by linear regression adjusting for pretreatment measure, stage, and grade. Although not statistically significant, mean ERβ expression was approximately 40% lower from pre- to postintervention in the FS + AI group only. We observed a statistically significant negative association (β ± SE -0.3 ± 0.1; P = 0.03) for androstenedione in the FS + AI group vs. placebo and for DHEA with AI treatment (β ± SE -1.6 ± 0.6; P = 0.009). Enterolactone excretion was much lower in the FS + AI group compared to the FS group. Our results do not support strong effects of FS on AI activity for selected breast tumor characteristics or serum steroid hormone levels but suggest AI therapy might reduce the production of circulating mammalian lignans from FS.
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U2 - 10.1080/01635581.2014.894097
DO - 10.1080/01635581.2014.894097
M3 - Article
C2 - 24669750
AN - SCOPUS:84899953791
VL - 66
SP - 566
EP - 575
JO - Nutrition and Cancer
JF - Nutrition and Cancer
SN - 0163-5581
IS - 4
ER -
