Un guide pratique au traitement des gliomes

Translated title of the contribution: A practical guide for the management of gliomas

Roger Stupp*, Alessia Pica, René O. Mirimanoff, Olivier Michielin

*Corresponding author for this work

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

The management of gliomas in daily clinical practice is challenging. It requires a multidisciplinary and coordinated approach involving neurosurgery, radiotherapy and, finally, chemotherapy. Important progress has been made during the last years with the introduction of a combined treatment associating standard radiotherapy with concomitant chemotherapy using temozolomide, a novel alkylating agent. For the first time in many years a new treatment strategy translated into a significant prolongation of survival. In parallel, molecular markers (e.g. loss of heterozygosity on chromosomes 1p and 19q or methylation of the methyl-guanine methyl transferase {MGMT} gene promoter) allowed for identification of distinct subtypes of glioma or prediction of treatment response. In this «Practical Guide», we describe the daily practice and aim at answering some common questions in the management of patients suffering from glioblastoma, astrocytoma, oligodendroglioma and low grade glioma. The therapeutic options presented here are based on evidences from the literature. In the absence of documented evidence, the empirical choices from our local practice are explained and justified.

Original languageFrench
Pages (from-to)817-822
Number of pages6
JournalBulletin du cancer
Volume94
Issue number9
DOIs
Publication statusPublished - Sep 1 2007

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Keywords

  • Glioma
  • Guidelines

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Stupp, R., Pica, A., Mirimanoff, R. O., & Michielin, O. (2007). Un guide pratique au traitement des gliomes. Bulletin du cancer, 94(9), 817-822. https://doi.org/10.1684/bdc.2007.0448