A precise chromatography system for specific technetium 99m radiopharmaceuticals

A. M. Zimmer, R. A. Holmes

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


New chromatographic procedures are needed to accurately determine the radiochemical purity of technetium 99m labeled radiopharmaceuticals. A chromatography system has been developed for technetium 99m diethylenetriaminepentaacetic acid, technetium 99m diphosphonate, and technetium 99m pyrophosphate. The technique involves spotting the radiopharmaceuticals on instant thin layer chromatography silica gel and developing with acetone (solvent front migrates approximately 12 cm from the origin), air drying, and redeveloping the strip in normal saline (solvent front migrates approximately 6 cm from the origin). The procedure is simple to perform, rapid, accurate, and clearly separates technetium 99m pertechnetate, the technetium 99m radiopharmaceutical, and hydrolyzed reduced technetium 99m. It can be applied in most nuclear medicine laboratories and has the potential to predict the quality of radionuclide images obtained.

Original languageEnglish (US)
Pages (from-to)192-195
Number of pages4
Issue number2
StatePublished - Dec 1 1975

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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