A precise polyrotaxane synthesizer

Yunyan Qiu, Bo Song, Cristian Pezzato, Dengke Shen, Wenqi Liu, Long Zhang, Yuanning Feng, Qing Hui Guo, Kang Cai, Weixingyue Li, Hongliang Chen, Minh T. Nguyen, Yi Shi, Chuyang Cheng, R. Dean Astumian, Xiaopeng Li, J. Fraser Stoddart*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

135 Scopus citations


Mechanically interlocked molecules are likely candidates for the design and synthesis of artificial molecular machines. Although polyrotaxanes have already found niche applications in exotic materials with specialized mechanical properties, efficient synthetic protocols to produce them with precise numbers of rings encircling their polymer dumbbells are still lacking. We report the assembly line-like emergence of poly[n]rotaxanes with increasingly higher energies by harnessing artificial molecular pumps to deliver rings in pairs by cyclical redox-driven processes. This programmable strategy leads to the precise incorporation of two, four, six, eight, and 10 rings carrying 8+, 16+, 24+, 32+, and 40+ charges, respectively, onto hexacationic polymer dumbbells. This strategy depends precisely on the number of redox cycles applied chemically or electrochemically, in both stepwise and one-pot manners.

Original languageEnglish (US)
Pages (from-to)1247-1253
Number of pages7
Issue number6496
StatePublished - Jun 12 2020

ASJC Scopus subject areas

  • General


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