A preliminary study of a health related quality of life assessment of priority symptoms in advanced lymphoma: The National Comprehensive Cancer Network-Functional Assessment of Cancer Therapy-Lymphoma Symptom Index

Fay J. Hlubocky*, Kimberly Webster, Jennifer Beaumont, John Cashy, Diane Paul, Amy Abernethy, Karen L. Syrjala, Jamie Von Roenn, David Cella

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Despite the recent advances in cancer therapeutics for lymphoma (Lym), a continuum of disease, treatment and psychological challenges, adversely impacting health-related quality of life, remain for the clinical management of the patient with Lym. In response, this study presents the development and validation of the National Comprehensive Cancer Network-Functional Assessment of Cancer Therapy (NCCN-FACT) Lymphoma Symptom Index-18 (FLymSI-18). Patients with advanced Lym (n = 50) rated the significance of 40 symptoms, and hematologist-oncologists (n = 10) rated these symptoms according to importance and disease-related or treatment-related origin. Patient symptom priorities were unified with clinician priorities for symptom measurement in Lym for instrument development. Reliability estimates indicate that FLymSI-18 has acceptable internal consistency (α = 0.87), content validity and concurrent validity as indicated by moderate to strong correlations with the FACIT (Functional Assessment of Chronic Illness Therapy). Overall, the FLymSI-18 provides evidence for its reliability and validity as a brief assessment of the most important symptoms associated with advanced Lym in the clinical trial research environment.

Original languageEnglish (US)
Pages (from-to)1942-1946
Number of pages5
JournalLeukemia and Lymphoma
Volume54
Issue number9
DOIs
StatePublished - Sep 2013

Keywords

  • FLymSI-18
  • HRQOL
  • Lymphoma
  • Symptom Index

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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