A primary encephalocele culture yields a pure population of human astrocytes

Ron L. Alterman*, Richard S. Morrison, James T. Goodrich, Peter Papenhausen, Joseph R. Moskal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


In order to develop a reliable source of human astrocytes for in vitro studies, we established a primary explant culture of a human encephalocele. This culture yielded a population of cells which were karyotypically normal, morphologically resembled astrocytes, expressed glial fibrillary acid protein, and responded mitogenically to exogenous growth factors. We conclude that white matter derived from human encephaloceles can be used to generate pure populations of normal astrocytes.

Original languageEnglish (US)
Pages (from-to)319-323
Number of pages5
JournalBrain research
Issue number2
StatePublished - Jun 7 1991


  • Astrocyte
  • Encephalocele
  • Glia cell culture
  • Glial fibrillary acid protein
  • Growth factor

ASJC Scopus subject areas

  • Clinical Neurology
  • Molecular Biology
  • General Neuroscience
  • Developmental Biology


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