A PROMIS fatigue short form for use by individuals who have multiple sclerosis

Karon F. Cook*, Alyssa M. Bamer, Toni S. Roddey, George H. Kraft, Jiseon Kim, Dagmar Amtmann

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Purpose: To derive from the Patient Reported Outcomes Measurement Information System (PROMIS) fatigue item bank, a short form for individuals with multiple sclerosis (MS), the PROMIS-Fatigue MS. Methods: A panel of 37 clinicians and 46 individuals with MS ranked the relevance of PROMIS fatigue items to persons with MS. Eight items were selected for the PROMIS-Fatigue MS that maximized relevance rankings, content coverage, and item discrimination. The PROMIS-Fatigue MS and an existing, 7-item PROMIS fatigue short form (PROMIS-Fatigue SFv1.0) were administered to a new sample of 231 individuals with MS. Known groups and content validity were assessed. Results: Scores from the short forms were highly correlated (r = 0.92). Discriminant validity of the PROMIS-Fatigue MS scores was supported in known groups comparisons. Scores of neither short form exhibited an advantage in quantitative analyses. The PROMIS-Fatigue MS targeted more of the content included in participants' responses to open-ended questions than did the PROMIS-Fatigue SFv1.0. Conclusions: The PROMIS-Fatigue MS was derived to have content validity in MS samples. The validity of the measure was further supported by the ability of PROMIS-Fatigue MS items to discriminate among groups expected to differ in levels of fatigue. We recommend its use in measuring the fatigue of individuals with MS.

Original languageEnglish (US)
Pages (from-to)1021-1030
Number of pages10
JournalQuality of Life Research
Issue number6
StatePublished - Aug 2012


  • Fatigue
  • Multiple sclerosis
  • Outcomes assessment
  • Psychometrics

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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