A Proposal for Separation of Nuclear Atypia and Architectural Atypia in Bethesda Category III (AUS/FLUS) Based on Differing Rates of Thyroid Malignancy

Daniel Johnson*, Allison B. Cavallo, Imran Uraizee, Kevin Tanager, Ricardo R. Lastra, Tatjana Antic, Nicole A. Cipriani

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Bethesda category III (atypia of undetermined significance/follicular lesion of undetermined significance) includes sparsely cellular specimens with nuclear atypia (3N) and/or architectural atypia (3A). This study investigates whether the two types of atypia have different rates of malignancy (ROMs). Methods: Cytologic and histologic diagnoses of resected thyroid nodules were recorded. ROM was calculated for all Bethesda categories and for 3N and 3A subcategories. Possible noninvasive follicular thyroid neoplasms with papillary-like nuclear features were reviewed and removed from malignancies, and ROM was recalculated.

Original languageEnglish (US)
Pages (from-to)86-94
Number of pages9
JournalAmerican journal of clinical pathology
Volume151
Issue number1
DOIs
StatePublished - Jan 1 2019

Keywords

  • Atypia of undetermined significance
  • Cancer
  • Cytology
  • FNA
  • Fine-needle aspiration
  • Follicular lesion of undetermined significance
  • Thyroid

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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