TY - JOUR
T1 - A prospective cohort study of early-pregnancy risk factors for gestational diabetes in polycystic ovarian syndrome
AU - Li, Guanghui
AU - Huang, Wenyu
AU - Zhang, Li
AU - Tian, Zhihong
AU - Zheng, Wei
AU - Wang, Teng
AU - Zhang, Ting
AU - Zhang, Weiyuan
N1 - Funding Information:
The authors thank the study subjects for their participation in this study. We thank Dr. Weiping Wang for assistance in statistical analysis, Mrs. Yan Zhao and Haojie Na for data collection and entry, and Dr. Xingdian Li for support with the bioassay. We also thank Dr. William Lowe Jr. for editing the manuscript. This study was supported by research grants from Beijing Capital Clinical Characteristic Research (Beijing Science and Technology Commission Z121107001012166 and Z161100000516160, Beijing, China) and Beijing High‐Level Talents Grant (Beijing Municipal Bureau of Health 2014‐3‐17, Beijing, China). Part of the results were presented in an oral presentation at the 98th Endocrine Society Annual Meeting, Boston, MA.
Funding Information:
Beijing Science and Technology Commission, Grant/Award Numbers: Z161100000516160 and Z121107001012166; Beijing Municipal Bureau of Health, Grant/Award Number: 2014‐3‐17; National Key Research and Development Program, Grant/Award Number: 2016YFC1000304
PY - 2018/7
Y1 - 2018/7
N2 - Background: Polycystic ovarian syndrome (PCOS) is a strong risk factor for gestational diabetes (GDM). However, the association between features of PCOS during early pregnancy and the risk of GDM is not clearly characterized. In this prospective cohort study, we seek to identify early-pregnancy risk factors for GDM in PCOS women. Methods: Between 2011 and 2013, 248 women with PCOS were followed from their first prenatal visit to delivery. Multiple early-pregnancy metabolic factors were evaluated for their association with the risk of GDM. Results: Among 248 subjects, 75 (30.2%) developed GDM. Single factor analysis identified a number of metabolic risk factors for GDM, including higher body mass index, fasting plasma glucose (FPG) and insulin resistance; abnormal cholesterol; elevated blood pressure and free androgen index; lower level of sex-hormone binding globulin (SHBG); and less gestational weight gain. Multivariate analysis showed that FPG, non–high-density lipoprotein-cholesterol and SHBG are independent predictive factors for GDM. Conclusions: Our study established strong association of multiple early-pregnancy risk factors with development of GDM in PCOS women. These risk factors are predominantly related to the regulation of glucose, lipid, and androgen metabolism. Among these factors, FPG, non–high-density lipoprotein-cholesterol, and SHBG, predict incident GDM.
AB - Background: Polycystic ovarian syndrome (PCOS) is a strong risk factor for gestational diabetes (GDM). However, the association between features of PCOS during early pregnancy and the risk of GDM is not clearly characterized. In this prospective cohort study, we seek to identify early-pregnancy risk factors for GDM in PCOS women. Methods: Between 2011 and 2013, 248 women with PCOS were followed from their first prenatal visit to delivery. Multiple early-pregnancy metabolic factors were evaluated for their association with the risk of GDM. Results: Among 248 subjects, 75 (30.2%) developed GDM. Single factor analysis identified a number of metabolic risk factors for GDM, including higher body mass index, fasting plasma glucose (FPG) and insulin resistance; abnormal cholesterol; elevated blood pressure and free androgen index; lower level of sex-hormone binding globulin (SHBG); and less gestational weight gain. Multivariate analysis showed that FPG, non–high-density lipoprotein-cholesterol and SHBG are independent predictive factors for GDM. Conclusions: Our study established strong association of multiple early-pregnancy risk factors with development of GDM in PCOS women. These risk factors are predominantly related to the regulation of glucose, lipid, and androgen metabolism. Among these factors, FPG, non–high-density lipoprotein-cholesterol, and SHBG, predict incident GDM.
KW - early pregnancy
KW - gestational diabetes
KW - polycystic ovarian syndrome
KW - risk factors
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U2 - 10.1002/dmrr.3003
DO - 10.1002/dmrr.3003
M3 - Article
C2 - 29514404
AN - SCOPUS:85045710663
SN - 1520-7552
VL - 34
JO - Diabetes/Metabolism Research and Reviews
JF - Diabetes/Metabolism Research and Reviews
IS - 5
M1 - e3003
ER -
