TY - JOUR
T1 - A prospective randomized trial comparing 6 versus 12 prostate biopsy cores
T2 - Impact on cancer detection
AU - Naughton, Cathy K.
AU - Miller, David C.
AU - Mager, Douglas E.
AU - Ornstein, David K.
AU - Catalona, William J.
PY - 2000/1/1
Y1 - 2000/1/1
N2 - Purpose: Several studies suggest that sextant transrectal ultrasound guided biopsy of the prostate provides insufficient material to detect all clinically important prostate cancer, and obtaining more biopsy cores may improve the cancer detection rate. We performed a prospective randomized trial comparing 6 to 12 prostate biopsy cores to determine the impact on the cancer detection rate. Materials and Methods: We prospectively randomized 244 men, including 71 (29%) black men, with a mean age plus or minus standard deviation of 65 ± 8 years to undergo biopsy with 6 or 12 peripheral zone tissue cores. In our study subjects serum total prostate specific antigen (PSA) was between 2.5 and 20 ng./ml., and/or digital rectal examination was suspicious for cancer. All men completed a self-administered pre-biopsy and 2 post-biopsy questionnaires at 2 and 4 weeks. Cancer detection rates were compared in the groups and correlated with race, biopsy history, digital rectal examination findings, total PSA, transrectal ultrasound volume and PSA density, as determined by the formula, total PSA/transrectal ultrasound volume. Results: The cancer detection rate in the 6 and 12 core groups was almost identical (26% and 27%, p = 0.9). There was no significant difference in cancer detection in the 2 trial arms with respect to subject race, biopsy history, digital rectal examination findings, total PSA, transrectal ultrasound volume or PSA density. However, our study did not have the statistical power to rule out small differences. Conclusions: The overall cancer detection rate is not materially increased by 12 core, peripheral zone biopsy in men in whom prostate cancer was mainly detected by screening.
AB - Purpose: Several studies suggest that sextant transrectal ultrasound guided biopsy of the prostate provides insufficient material to detect all clinically important prostate cancer, and obtaining more biopsy cores may improve the cancer detection rate. We performed a prospective randomized trial comparing 6 to 12 prostate biopsy cores to determine the impact on the cancer detection rate. Materials and Methods: We prospectively randomized 244 men, including 71 (29%) black men, with a mean age plus or minus standard deviation of 65 ± 8 years to undergo biopsy with 6 or 12 peripheral zone tissue cores. In our study subjects serum total prostate specific antigen (PSA) was between 2.5 and 20 ng./ml., and/or digital rectal examination was suspicious for cancer. All men completed a self-administered pre-biopsy and 2 post-biopsy questionnaires at 2 and 4 weeks. Cancer detection rates were compared in the groups and correlated with race, biopsy history, digital rectal examination findings, total PSA, transrectal ultrasound volume and PSA density, as determined by the formula, total PSA/transrectal ultrasound volume. Results: The cancer detection rate in the 6 and 12 core groups was almost identical (26% and 27%, p = 0.9). There was no significant difference in cancer detection in the 2 trial arms with respect to subject race, biopsy history, digital rectal examination findings, total PSA, transrectal ultrasound volume or PSA density. However, our study did not have the statistical power to rule out small differences. Conclusions: The overall cancer detection rate is not materially increased by 12 core, peripheral zone biopsy in men in whom prostate cancer was mainly detected by screening.
KW - Biopsy
KW - Diagnosis
KW - Prostate
KW - Prostatic neoplasms
KW - Ultrasonography
UR - http://www.scopus.com/inward/record.url?scp=0033926998&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033926998&partnerID=8YFLogxK
U2 - 10.1016/S0022-5347(05)67367-3
DO - 10.1016/S0022-5347(05)67367-3
M3 - Article
C2 - 10893592
AN - SCOPUS:0033926998
SN - 0022-5347
VL - 164
SP - 388
EP - 392
JO - Journal of Urology
JF - Journal of Urology
IS - 2
ER -