A prospective study for treatment of nasal valve collapse due to lateral wall insufficiency

Outcomes using a bioabsorbable implant

Pablo Stolovitzky, Douglas Mathew Sidle, Randall A. Ow, Nathan E. Nachlas, Sam P. Most*

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: To examine 6-month outcomes for treatment of lateral nasal wall insufficiency with a bioabsorbable implant. Study Design: Prospective, multicenter, nonrandomized, single-blinded study. Methods: One hundred and one patients with severe-to-extreme class of Nasal Obstruction Symptom Evaluation (NOSE) scores were enrolled at 14 U.S. clinics (September 2016–March 2017). Patients were treated with a bioabsorbable implant designed to support lateral wall, with or without concurrent septoplasty and/or turbinate reduction procedure(s). NOSE scores and visual analog scale (VAS) were measured at baseline and month 1, 3, and 6 postoperatively. The Lateral Wall Insufficiency (LWI) score was determined by independent physicians observing the lateral wall motion video. Results: Forty-three patients were treated with implant alone, whereas 58 had adjunctive procedures. Seventeen patients reported 19 adverse events, all of which resolved with no clinical sequelae. Patients showed significant reduction in NOSE scores at 1, 3, and 6 months postoperatively (79.5 ± 13.5 preoperatively, 34.6 ± 25.0 at 1 month, 32.0 ± 28.4 at 3 months, and 30.6 ± 25.8 at 6 months postoperatively; P < 0.01 for all). They also showed significant reduction in VAS scores postoperatively (71.9 ± 18.8 preoperatively, 32.7 ± 27.1 at 1 month, 30.1 ± 28.3 at 3 months, and 30.7 ± 29.6 at 6 months postoperatively; P < 0.01 for all). These results were similar in patients treated with the implant alone compared to those treated with the implant and adjunctive procedures. Consistent with patient-reported outcomes, postoperative LWI scores were demonstrably lower (1.83 ± 0.10 and 1.30 ± 0.11 pre- and postoperatively; P < 0.01). Conclusion: Stabilization of the lateral nasal wall with a bioabsorbable implant improves patients' nasal obstructive symptoms over 6 months. Level of Evidence: 2b. Laryngoscope, 2483–2489, 2018.

Original languageEnglish (US)
Pages (from-to)2483-2489
Number of pages7
JournalLaryngoscope
Volume128
Issue number11
DOIs
StatePublished - Nov 1 2018

Fingerprint

Absorbable Implants
Nose
Prospective Studies
Nasal Obstruction
Symptom Assessment
Visual Analog Scale
Therapeutics
Laryngoscopes
Turbinates
Physicians

Keywords

  • Nasal valve
  • lateral wall insufficiency
  • nasal implant
  • nasal obstruction
  • valve repair

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Stolovitzky, Pablo ; Sidle, Douglas Mathew ; Ow, Randall A. ; Nachlas, Nathan E. ; Most, Sam P. / A prospective study for treatment of nasal valve collapse due to lateral wall insufficiency : Outcomes using a bioabsorbable implant. In: Laryngoscope. 2018 ; Vol. 128, No. 11. pp. 2483-2489.
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title = "A prospective study for treatment of nasal valve collapse due to lateral wall insufficiency: Outcomes using a bioabsorbable implant",
abstract = "Objective: To examine 6-month outcomes for treatment of lateral nasal wall insufficiency with a bioabsorbable implant. Study Design: Prospective, multicenter, nonrandomized, single-blinded study. Methods: One hundred and one patients with severe-to-extreme class of Nasal Obstruction Symptom Evaluation (NOSE) scores were enrolled at 14 U.S. clinics (September 2016–March 2017). Patients were treated with a bioabsorbable implant designed to support lateral wall, with or without concurrent septoplasty and/or turbinate reduction procedure(s). NOSE scores and visual analog scale (VAS) were measured at baseline and month 1, 3, and 6 postoperatively. The Lateral Wall Insufficiency (LWI) score was determined by independent physicians observing the lateral wall motion video. Results: Forty-three patients were treated with implant alone, whereas 58 had adjunctive procedures. Seventeen patients reported 19 adverse events, all of which resolved with no clinical sequelae. Patients showed significant reduction in NOSE scores at 1, 3, and 6 months postoperatively (79.5 ± 13.5 preoperatively, 34.6 ± 25.0 at 1 month, 32.0 ± 28.4 at 3 months, and 30.6 ± 25.8 at 6 months postoperatively; P < 0.01 for all). They also showed significant reduction in VAS scores postoperatively (71.9 ± 18.8 preoperatively, 32.7 ± 27.1 at 1 month, 30.1 ± 28.3 at 3 months, and 30.7 ± 29.6 at 6 months postoperatively; P < 0.01 for all). These results were similar in patients treated with the implant alone compared to those treated with the implant and adjunctive procedures. Consistent with patient-reported outcomes, postoperative LWI scores were demonstrably lower (1.83 ± 0.10 and 1.30 ± 0.11 pre- and postoperatively; P < 0.01). Conclusion: Stabilization of the lateral nasal wall with a bioabsorbable implant improves patients' nasal obstructive symptoms over 6 months. Level of Evidence: 2b. Laryngoscope, 2483–2489, 2018.",
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A prospective study for treatment of nasal valve collapse due to lateral wall insufficiency : Outcomes using a bioabsorbable implant. / Stolovitzky, Pablo; Sidle, Douglas Mathew; Ow, Randall A.; Nachlas, Nathan E.; Most, Sam P.

In: Laryngoscope, Vol. 128, No. 11, 01.11.2018, p. 2483-2489.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A prospective study for treatment of nasal valve collapse due to lateral wall insufficiency

T2 - Outcomes using a bioabsorbable implant

AU - Stolovitzky, Pablo

AU - Sidle, Douglas Mathew

AU - Ow, Randall A.

AU - Nachlas, Nathan E.

AU - Most, Sam P.

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N2 - Objective: To examine 6-month outcomes for treatment of lateral nasal wall insufficiency with a bioabsorbable implant. Study Design: Prospective, multicenter, nonrandomized, single-blinded study. Methods: One hundred and one patients with severe-to-extreme class of Nasal Obstruction Symptom Evaluation (NOSE) scores were enrolled at 14 U.S. clinics (September 2016–March 2017). Patients were treated with a bioabsorbable implant designed to support lateral wall, with or without concurrent septoplasty and/or turbinate reduction procedure(s). NOSE scores and visual analog scale (VAS) were measured at baseline and month 1, 3, and 6 postoperatively. The Lateral Wall Insufficiency (LWI) score was determined by independent physicians observing the lateral wall motion video. Results: Forty-three patients were treated with implant alone, whereas 58 had adjunctive procedures. Seventeen patients reported 19 adverse events, all of which resolved with no clinical sequelae. Patients showed significant reduction in NOSE scores at 1, 3, and 6 months postoperatively (79.5 ± 13.5 preoperatively, 34.6 ± 25.0 at 1 month, 32.0 ± 28.4 at 3 months, and 30.6 ± 25.8 at 6 months postoperatively; P < 0.01 for all). They also showed significant reduction in VAS scores postoperatively (71.9 ± 18.8 preoperatively, 32.7 ± 27.1 at 1 month, 30.1 ± 28.3 at 3 months, and 30.7 ± 29.6 at 6 months postoperatively; P < 0.01 for all). These results were similar in patients treated with the implant alone compared to those treated with the implant and adjunctive procedures. Consistent with patient-reported outcomes, postoperative LWI scores were demonstrably lower (1.83 ± 0.10 and 1.30 ± 0.11 pre- and postoperatively; P < 0.01). Conclusion: Stabilization of the lateral nasal wall with a bioabsorbable implant improves patients' nasal obstructive symptoms over 6 months. Level of Evidence: 2b. Laryngoscope, 2483–2489, 2018.

AB - Objective: To examine 6-month outcomes for treatment of lateral nasal wall insufficiency with a bioabsorbable implant. Study Design: Prospective, multicenter, nonrandomized, single-blinded study. Methods: One hundred and one patients with severe-to-extreme class of Nasal Obstruction Symptom Evaluation (NOSE) scores were enrolled at 14 U.S. clinics (September 2016–March 2017). Patients were treated with a bioabsorbable implant designed to support lateral wall, with or without concurrent septoplasty and/or turbinate reduction procedure(s). NOSE scores and visual analog scale (VAS) were measured at baseline and month 1, 3, and 6 postoperatively. The Lateral Wall Insufficiency (LWI) score was determined by independent physicians observing the lateral wall motion video. Results: Forty-three patients were treated with implant alone, whereas 58 had adjunctive procedures. Seventeen patients reported 19 adverse events, all of which resolved with no clinical sequelae. Patients showed significant reduction in NOSE scores at 1, 3, and 6 months postoperatively (79.5 ± 13.5 preoperatively, 34.6 ± 25.0 at 1 month, 32.0 ± 28.4 at 3 months, and 30.6 ± 25.8 at 6 months postoperatively; P < 0.01 for all). They also showed significant reduction in VAS scores postoperatively (71.9 ± 18.8 preoperatively, 32.7 ± 27.1 at 1 month, 30.1 ± 28.3 at 3 months, and 30.7 ± 29.6 at 6 months postoperatively; P < 0.01 for all). These results were similar in patients treated with the implant alone compared to those treated with the implant and adjunctive procedures. Consistent with patient-reported outcomes, postoperative LWI scores were demonstrably lower (1.83 ± 0.10 and 1.30 ± 0.11 pre- and postoperatively; P < 0.01). Conclusion: Stabilization of the lateral nasal wall with a bioabsorbable implant improves patients' nasal obstructive symptoms over 6 months. Level of Evidence: 2b. Laryngoscope, 2483–2489, 2018.

KW - Nasal valve

KW - lateral wall insufficiency

KW - nasal implant

KW - nasal obstruction

KW - valve repair

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