A psychophysiological investigation of threat and reward sensitivity in individuals with panic disorder and/or major depressive disorder

Stewart A Shankman*, Brady D. Nelson, Casey Sarapas, Jenna E. Robison-Andrew, Miranda L. Campbell, Sarah E. Altman, Sarah Kate McGowan, Andrea C. Katz, Stephanie M. Gorka

*Corresponding author for this work

Research output: Contribution to journalArticle

103 Scopus citations

Abstract

Heightened sensitivity to threat and reduced sensitivity to reward are potential mechanisms of dysfunction in anxiety and depressive disorders, respectively. However, few sudies have simultaneously examined whether these mechanisms are unique or common to these disorders. In this study, sensitivity to predictable and unpredictable threat (measured by startle response during threat anticipation) and sensitivity to reward (measured by frontal electroencephalographic [EEG] asymmetry during reward anticipation) were assessed in4 groups (N = 191): those with (1) panic disorder (PD) without a lifetime history of depression, (2) major depression (MDD) without a lifetime history of an anxiety disorder, (3)comorbid PD and MDD, and (4) controls. General distress/negative temperament (NT) was also assessed via self-report. Results indicated that PD (with or without comorbid MDD) was uniquely associated with heightened startle to predictable and unpredictable threat, and MDD (with or without comorbid PD) was uniquely associated with reduced frontal EEG asymmetry. Both psychophysiological measures of threat and reward sensitivity were stable on retest approximately 9 days later in a subsample of participants. Whereas the comorbid group did not respond differently on the tasks relative to the PD-only and MDD-only groups,they did report greater NT than these 2 groups (which did not differ from each other). Results suggest that heightened sensitivity to threat and reduced sensitivity to reward maybe specific components of PD and MDD, respectively. In addition, relative to noncomorbid depression and PD, comorbid MDD and PD may be characterized by heightened NT, but not abnormal levels of these "specific" components.

Original languageEnglish (US)
Pages (from-to)322-338
Number of pages17
JournalJournal of abnormal psychology
Volume122
Issue number2
DOIs
StatePublished - Jan 1 2013

Keywords

  • Anxiety
  • Comorbidity
  • Depression
  • Electroencephalography
  • Startle

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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    Shankman, S. A., Nelson, B. D., Sarapas, C., Robison-Andrew, J. E., Campbell, M. L., Altman, S. E., McGowan, S. K., Katz, A. C., & Gorka, S. M. (2013). A psychophysiological investigation of threat and reward sensitivity in individuals with panic disorder and/or major depressive disorder. Journal of abnormal psychology, 122(2), 322-338. https://doi.org/10.1037/a0030747