A randomized controlled trial of Filgrastim as an adjunct to antibiotics for treatment of hospitalized patients with community-acquired pneumonia

Steve Nelson*, Steven M. Belknap, Richard W. Carlson, David Dale, Ben DeBoisblanc, Stephen Farkas, Nick Fotheringham, Hoi Ho, Thomas Marrie, Hassan Movahhed, Richard Root, John Wilson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

169 Scopus citations

Abstract

Because of the critical role of neutrophils in host defenses, it was hypothesized that stimulation of neutrophil production and function with Filgrastim would improve the outcome of hospitalized patients with community- acquired pneumonia. To test this hypothesis, a randomized, placebo- controlled, multicenter trial of Filgrastim (300 μg/day up to 10 days) as an adjunct to antibiotics was conducted for these patients. Outcome measures included time to resolution of morbidity (TRM, a composite measure of temperature, respiratory rate, blood oxygenation, and chest radiograph), 28- day mortality, length of stay, and adverse events. Filgrastim increased blood neutrophils 3-fold, but TRM, mortality, and length of hospitalization were not affected. Treatment, however, accelerated radiologic improvement and appeared to reduce serious complications (e.g., empyema, adult respiratory distress syndrome, and disseminated intravascular coagulation). Filgrastim administration was safe and well tolerated in these patients. Additional trials are needed to establish the value of this approach to treatment of infectious diseases.

Original languageEnglish (US)
Pages (from-to)1075-1080
Number of pages6
JournalJournal of Infectious Diseases
Volume178
Issue number4
DOIs
StatePublished - 1998

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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