A randomized trial of a prenatal genetic testing interactive computerized information aid

Objective: The aim of this study was to determine whether an interactive computer program could improve patient knowledge regarding genetic screening and diagnostic concepts. Methods: In this randomized trial, women 6-26weeks' gestation were assigned to standard care with provider-based counseling or to augmented counseling with an interactive computer program. The computer-based tool conveyed information about genetic testing options. Women were administered a 23-item test of content knowledge immediately and 2-4weeks after exposure. Test scores were compared between groups at both points using T-tests. Results: A total of 150 women were randomized equally between groups. Groups were similar with regard to demographic characteristics. Women randomized to the interactive tool correctly answered a significantly greater proportion of questions than those who received standard counseling (69.4%±14.2% vs. 46.0%±15.2%, p<0.001) on the immediate questionnaire. One hundred and twenty-three (82%) participants participated in the follow-up test. Women randomized to the tool continued to correctly answer a significantly greater proportion of questions (60.6%±16% vs. 49.7%±18.9%, p=0.001). Education, health literacy, electronic health literacy, and other discussions with providers were not associated with a differential benefit from the educational intervention. Conclusion: A patient-directed interactive computer program may help providers to convey relevant information about genetic screening and diagnostic concepts.