A randomized trial on the effect of decreased dietary sodium intake on blood pressure in adolescents

Richard Cooper*, Linda Van Horn, Kiang Liu, Maurizio Trevisan, Seraphim Nanas, Hirotsugu Ueshima, Emmanuel Larbi, Chiu Sheng Yu, Christopher Sempos, Dan Legrady, Jeremiah Stamler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


A randomized crossover trial on the effect of salt restriction on blood pressure was carried out involving 124 adolescents (mean age 16 years). Dietary sodium was reduced from approximately 110 to 45 mEq/24 h for a period of 24 days. Blood pressure was non-significantly lower at the end of the experimental diet for all participants. A slight (0.7 kg), yet statistically significant fall in weight was observed (P < 0.05). Subgroup analysis demonstrated that participants whose body mass index was below the median had a statistically significant fall in systolic blood pressure (P < 0.05); fall in weight and increase in heart rate were also more pronounced in the less obese individuals. It would appear that moderate sodium reduction does not have an overall short-term effect on blood pressure in normotensive adolescents. However, body size as reflected in body mass index may influence blood pressure response to sodium reduction.

Original languageEnglish (US)
Pages (from-to)361-366
Number of pages6
JournalJournal of hypertension
Issue number4
StatePublished - Aug 1984


  • Blood pressure
  • Randomized trial
  • Salt

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine


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