A Rare Case of Granulomatous Interstitial Nephritis in a Patient With COVID-19

Manal Alotaibi*, Carla Ellis, Shikha Wadhwani, Yonatan Peleg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Acute kidney injury (AKI) in patients with coronavirus disease 2019 (COVID-19) is common, especially among severely ill patients. While acute tubular necrosis (ATN) is one of the most common findings in published kidney biopsy series for patients with COVID-19 infections, a number of glomerular pathologies have been described as well. Among glomerular pathologies in COVID-19, COVID-19-Associated Collapsing Glomerulopathy (COVAN) remains the most common pattern of injury. Patients with 2 high-risk APOL1 alleles appear to be at increased risk for COVAN, similar to other forms of collapsing glomerulopathy such as HIV-Associated Nephropathy. Acute interstitial nephritis (AIN) is a less common finding in patients with COVID-19 and reported cases have been mild. Reports of a subtype of AIN, granulomatous interstitial nephritis (GIN), among COVID-19 patients are extremely rare and have not been reported in association with COVAN. Here, we report a case of COVAN associated with severe GIN.

Original languageEnglish (US)
JournalJournal of Investigative Medicine High Impact Case Reports
StatePublished - 2022


  • AIN
  • AKI
  • COVID-19
  • GIN
  • nephrology

ASJC Scopus subject areas

  • Safety, Risk, Reliability and Quality
  • Epidemiology
  • Safety Research


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