A rare case of prostatic ductal adenocarcinoma presenting as papillary metastatic carcinoma of unknown primary: A case report and review of the literature

Erik R. Washburn, Grace W. Weyant, Ximing J Yang, Zhaohai Yang*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Prostatic ductal adenocarcinoma is an uncommon form of prostatic carcinoma. We report a case of a 63-year-old man who presented with non-infective thrombotic (marantic) endocarditis and an incidental finding of a destructive lesion in the left iliac crest. Core biopsy of the lesion showed a carcinoma with papillary architecture and was initially diagnosed as “metastatic carcinoma of unknown origin”. The patient experienced a cerebral infarction and expired six days later. Postmortem examination revealed extensive mixed acinar and ductal adenocarcinoma (Gleason score 5 + 4 = 9) in the prostate. Further studies confirmed the bone lesion as metastatic prostatic ductal adenocarcinoma. Although rare, metastatic prostatic adenocarcinoma should be considered in the differential diagnosis in a male patient when the carcinoma shows predominantly papillary architectures. A review of literature is presented to enhance the awareness of this entity.

Original languageEnglish (US)
Pages (from-to)26-31
Number of pages6
JournalHuman Pathology: Case Reports
Volume6
DOIs
StatePublished - Dec 1 2016

Keywords

  • Ductal carcinoma
  • Neoplasm metastasis
  • Prostatic neoplasms
  • Unknown primary neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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