A rationally designed cocatalyst for the Morita-Baylis-Hillman reaction

Charlotte E.S. Jones, Simon M. Turega, Matthew L. Clarke*, Douglas Philp

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


The application of electronic structure calculations to a key transition state in the reaction manifold of the Morita-Baylis-Hillman reaction allows the design of two bis(thiourea) cocatalysts capable of accelerating this reaction through the hydrogen bond mediated recognition of both the nucleophile and the electrophile.

Original languageEnglish (US)
Pages (from-to)4666-4669
Number of pages4
JournalTetrahedron Letters
Issue number31
StatePublished - Jul 28 2008

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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