A Redox-Switchable, Allosteric Coordination Complex

Ho Fung Cheng, Andrea I. D'Aquino, Joaquín Barroso-Flores, Chad A. Mirkin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


A redox-regulated molecular tweezer complex was synthesized via the weak-link approach. The PtII complex features a redox-switchable hemilabile ligand (RHL) functionalized with a ferrocenyl moiety, whose oxidation state modulates the opening of a specific coordination site. Allosteric regulation by redox agents gives reversible access to two distinct structural states - a fully closed state and a semi-open state - whose interconversion was studied via multinuclear NMR spectroscopy, cyclic voltammetry, and UV-vis-NIR spectroscopy. Two structures in this four-state system were further characterized via SCXRD, while the others were modeled through DFT calculations. This fully reversible, RHL-based system defines an unusual level of electrochemical control over the occupancy of a specific coordination site, thereby providing access to four distinct coordination states within a single system, each defined and differentiated by structure and oxidation state.

Original languageEnglish (US)
Pages (from-to)14590-14594
Number of pages5
JournalJournal of the American Chemical Society
Issue number44
StatePublished - Nov 7 2018

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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