A retrospective multicenter analysis of elderly Hodgkin lymphoma: Outcomes and prognostic factors in the modern era

Andrew M. Evens*, Irene Helenowski, Erika Ramsdale, Chadi Nabhan, Reem Karmali, Britt Hanson, Benjamin Parsons, Scott Smith, Annette Larsen, June M. McKoy, Borko Jovanovic, Stephanie Gregory, Leo I. Gordon, Sonali M. Smith

*Corresponding author for this work

Research output: Contribution to journalArticle

82 Scopus citations

Abstract

We investigated a recent (January 1999 to December 2009) cohort of 95 elderly Hodgkin lymphoma subjects. At diagnosis, median age was 67 years (range, 60-89 years), whereas 61% had significant comorbidity, 26% were unfit, 17% had a geriatric syndrome, and 13% had loss of activities of daily living. Overall response rate to therapy was 85%, whereas incidence of bleomycin lung toxicity was 32% (with associated mortality rate, 25%). With 66-month median follow-up, 2-year and 5-year overall survival were 73% and 58%, respectively (advanced-stage, 63% and 46%, respectively). Most International Prognostic Score factors were not prognostic on univariate analyses, whereas Cox multivariate regression identified 2 risk factors associated with inferior overall survival: (1) age more than 70 years (2.24; 95% CI, 1.16-4.33, P = .02) and (2) loss of activities of daily living (2.71; 95% CI, 1.07-6.84, P = .04). Furthermore, a novel survival model based on number of these risk factors (0, 1, or 2) showed differential 2-year OS of 83%, 70%, and 13%, respectively (P < .0001) and 5-year OS of 73%, 51%, and 0%, respectively (P < .0001).

Original languageEnglish (US)
Pages (from-to)692-695
Number of pages4
JournalBlood
Volume119
Issue number3
DOIs
StatePublished - Jan 19 2012

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ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Evens, A. M., Helenowski, I., Ramsdale, E., Nabhan, C., Karmali, R., Hanson, B., Parsons, B., Smith, S., Larsen, A., McKoy, J. M., Jovanovic, B., Gregory, S., Gordon, L. I., & Smith, S. M. (2012). A retrospective multicenter analysis of elderly Hodgkin lymphoma: Outcomes and prognostic factors in the modern era. Blood, 119(3), 692-695. https://doi.org/10.1182/blood-2011-09-378414