A retrospective study to describe the epidemiology and outcomes of opportunistic infections after abdominal organ transplantation

Mia Helfrich, Peter Dorschner, Kathryn Thomas, Valentina Stosor, Michael G Ison*

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Most epidemiologic studies of opportunistic infections (OI) following abdominal organ transplantation are derived prior to the era of contemporary immunosuppression and prophylaxis. These studies suggest that most OI occur within the first 6 months post transplant. Method: In this single-center, retrospective cohort study, we describe the epidemiology of OI in 359 consecutive abdominal organ transplant recipients, in the era of contemporary prophylaxis practices and alemtuzumab induction in kidney and simultaneous pancreas-kidney transplant recipients. Results: Ninety patients (25.1%) developed OI, with 53.3% of these occurring beyond 6 months. The most common OI were BK polyomavirus nephropathy (5.0%), cytomegalovirus (10.2%), varicella zoster virus (4.4%), and herpes simplex virus (1.1%), which typically occurred after discontinuation of antiviral prophylaxis, and Clostridium difficile infections (7.8%). Conclusion: OI had no impact on patient or graft survival at 12 months post transplant. In the era of contemporary immunosuppression and prophylaxis, a significant proportion of OI occur beyond 6 months. Additional strategies may be important to reduce the incidence of such late-onset infections.

Original languageEnglish (US)
Article numbere12691
JournalTransplant Infectious Disease
Volume19
Issue number3
DOIs
StatePublished - Jun 1 2017

Fingerprint

Opportunistic Infections
Organ Transplantation
Epidemiology
Retrospective Studies
Transplants
Immunosuppression
BK Virus
Clostridium Infections
Kidney
Human Herpesvirus 3
Clostridium difficile
Graft Survival
Simplexvirus
Cytomegalovirus
Antiviral Agents
Epidemiologic Studies
Pancreas
Cohort Studies
Incidence
Infection

Keywords

  • abdominal organ transplant
  • alemtuzumab
  • opportunistic infections

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

Cite this

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title = "A retrospective study to describe the epidemiology and outcomes of opportunistic infections after abdominal organ transplantation",
abstract = "Background: Most epidemiologic studies of opportunistic infections (OI) following abdominal organ transplantation are derived prior to the era of contemporary immunosuppression and prophylaxis. These studies suggest that most OI occur within the first 6 months post transplant. Method: In this single-center, retrospective cohort study, we describe the epidemiology of OI in 359 consecutive abdominal organ transplant recipients, in the era of contemporary prophylaxis practices and alemtuzumab induction in kidney and simultaneous pancreas-kidney transplant recipients. Results: Ninety patients (25.1{\%}) developed OI, with 53.3{\%} of these occurring beyond 6 months. The most common OI were BK polyomavirus nephropathy (5.0{\%}), cytomegalovirus (10.2{\%}), varicella zoster virus (4.4{\%}), and herpes simplex virus (1.1{\%}), which typically occurred after discontinuation of antiviral prophylaxis, and Clostridium difficile infections (7.8{\%}). Conclusion: OI had no impact on patient or graft survival at 12 months post transplant. In the era of contemporary immunosuppression and prophylaxis, a significant proportion of OI occur beyond 6 months. Additional strategies may be important to reduce the incidence of such late-onset infections.",
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A retrospective study to describe the epidemiology and outcomes of opportunistic infections after abdominal organ transplantation. / Helfrich, Mia; Dorschner, Peter; Thomas, Kathryn; Stosor, Valentina; Ison, Michael G.

In: Transplant Infectious Disease, Vol. 19, No. 3, e12691, 01.06.2017.

Research output: Contribution to journalArticle

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