A review of biomarkers and physiomarkers in pediatric sepsis

Mashael F. Alqahtani, Lauren E. Marsillio, Ranna A. Rozenfeld*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Sepsis is a leading cause of morbidity and mortality in critically ill pediatric patients. The early diagnosis of sepsis is often difficult. Clinical signs and symptoms consistent with established criteria often occur late in the course of illness. In addition, early manifestations of sepsis are often nonspecific and can occur in many other disease processes, which confound the clinical picture. Therefore, identifying markers that are both sensitive and specific would be extremely helpful to the clinician for definitive diagnosis of sepsis before progression to severe disease. The purpose of this review is to describe the more common physiomarkers and biomarkers used that may aid in the diagnosis of sepsis as well as describe promising biomarkers that may be more widely available in the future.

Original languageEnglish (US)
Pages (from-to)177-184
Number of pages8
JournalClinical Pediatric Emergency Medicine
Issue number2
StatePublished - Jun 2014


  • Biomarker
  • C-reactive protein
  • CD-64
  • Interleukin 6
  • Interleukin 8
  • Lactate
  • Pediatrics
  • Procalcitonin
  • Sepsis
  • Soluble triggering receptor expressed on myeloid cells 1

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Emergency Medicine


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