A Review of High-Dimensional Mediation Analyses in DNA Methylation Studies

Haixiang Zhang; Lifang Hou; Lei Liu

doi:10.1007/978-1-0716-1994-0_10

A Review of High-Dimensional Mediation Analyses in DNA Methylation Studies

Haixiang Zhang, Lifang Hou, Lei Liu^*

^*Corresponding author for this work

Preventive Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

5 Scopus citations

Abstract

DNA methylation alterations have been widely studied as mediators of environmentally induced disease risks. With new advances in technique, epigenome-wide DNA methylation data (EWAS) have become the new standard for epigenetic studies in human populations. However, to date most epigenetic studies of mediation effects only involve selected (gene-specific) candidate methylation markers. There is an urgent need for appropriate analytical methods for EWAS mediation analysis. In this chapter, we provide an overview of recent advances on high-dimensional mediation analysis, with application to two DNA methylation data.

Original language	English (US)
Title of host publication	Methods in Molecular Biology
Publisher	Humana Press Inc.
Pages	123-135
Number of pages	13
DOIs	https://doi.org/10.1007/978-1-0716-1994-0_10
State	Published - 2022

Publication series

Name	Methods in Molecular Biology
Volume	2432
ISSN (Print)	1064-3745
ISSN (Electronic)	1940-6029

Funding

The work of Haixiang Zhang is partially supported by Science Foundation of Tianjin University (No. 2018XRG-0038). The work of Lei Liu is partially supported by the Washington University Institute of Clinical and Translational Sciences grant UL1TR000448 from the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH) and NIH R21 AG063370.

Keywords

Epigenetics
False discovery rate
Joint significance test
Mediation analysis
Multiple comparison
Regularization
Variable selection

ASJC Scopus subject areas

Genetics
Molecular Biology

Access to Document

10.1007/978-1-0716-1994-0_10

Cite this

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abstract = "DNA methylation alterations have been widely studied as mediators of environmentally induced disease risks. With new advances in technique, epigenome-wide DNA methylation data (EWAS) have become the new standard for epigenetic studies in human populations. However, to date most epigenetic studies of mediation effects only involve selected (gene-specific) candidate methylation markers. There is an urgent need for appropriate analytical methods for EWAS mediation analysis. In this chapter, we provide an overview of recent advances on high-dimensional mediation analysis, with application to two DNA methylation data.",

keywords = "Epigenetics, False discovery rate, Joint significance test, Mediation analysis, Multiple comparison, Regularization, Variable selection",

author = "Haixiang Zhang and Lifang Hou and Lei Liu",

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N2 - DNA methylation alterations have been widely studied as mediators of environmentally induced disease risks. With new advances in technique, epigenome-wide DNA methylation data (EWAS) have become the new standard for epigenetic studies in human populations. However, to date most epigenetic studies of mediation effects only involve selected (gene-specific) candidate methylation markers. There is an urgent need for appropriate analytical methods for EWAS mediation analysis. In this chapter, we provide an overview of recent advances on high-dimensional mediation analysis, with application to two DNA methylation data.

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KW - Epigenetics

KW - False discovery rate

KW - Joint significance test

KW - Mediation analysis

KW - Multiple comparison

KW - Regularization

KW - Variable selection

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A Review of High-Dimensional Mediation Analyses in DNA Methylation Studies

Abstract

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Keywords

ASJC Scopus subject areas

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