A Review of Phase II Acute Heart Failure Syndromes Clinical Trials

Peter S. Pang; Mihai Gheorghiade

doi:10.1016/j.hfc.2011.06.002

A Review of Phase II Acute Heart Failure Syndromes Clinical Trials

Peter S. Pang^*, Mihai Gheorghiade

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Hospitalization for acute heart failure syndromes (AHFS) is a growing health care burden. Over 1 million hospitalizations occur annually, with a postdischarge mortality and rehospitalization rate of ~45% by 90 days and a financial cost greater than $20 billion. Attempts to improve outcomes through novel therapies have largely failed, suggesting new approaches are needed. We review phase II studies in AHFS to identify opportunities for future development programs.

Original language	English (US)
Pages (from-to)	441-450
Number of pages	10
Journal	Heart Failure Clinics
Volume	7
Issue number	4
DOIs	https://doi.org/10.1016/j.hfc.2011.06.002
State	Published - Oct 2011

Keywords

Acute heart failure
Clinical trials
Phase 2

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.hfc.2011.06.002

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title = "A Review of Phase II Acute Heart Failure Syndromes Clinical Trials",

abstract = "Hospitalization for acute heart failure syndromes (AHFS) is a growing health care burden. Over 1 million hospitalizations occur annually, with a postdischarge mortality and rehospitalization rate of ~45% by 90 days and a financial cost greater than $20 billion. Attempts to improve outcomes through novel therapies have largely failed, suggesting new approaches are needed. We review phase II studies in AHFS to identify opportunities for future development programs.",

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AB - Hospitalization for acute heart failure syndromes (AHFS) is a growing health care burden. Over 1 million hospitalizations occur annually, with a postdischarge mortality and rehospitalization rate of ~45% by 90 days and a financial cost greater than $20 billion. Attempts to improve outcomes through novel therapies have largely failed, suggesting new approaches are needed. We review phase II studies in AHFS to identify opportunities for future development programs.

KW - Acute heart failure

KW - Clinical trials

KW - Phase 2

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A Review of Phase II Acute Heart Failure Syndromes Clinical Trials

Abstract

Keywords

ASJC Scopus subject areas

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