A Review of Phase II Acute Heart Failure Syndromes Clinical Trials

Peter S. Pang*, Mihai Gheorghiade

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Hospitalization for acute heart failure syndromes (AHFS) is a growing health care burden. Over 1 million hospitalizations occur annually, with a postdischarge mortality and rehospitalization rate of ~45% by 90 days and a financial cost greater than $20 billion. Attempts to improve outcomes through novel therapies have largely failed, suggesting new approaches are needed. We review phase II studies in AHFS to identify opportunities for future development programs.

Original languageEnglish (US)
Pages (from-to)441-450
Number of pages10
JournalHeart Failure Clinics
Issue number4
StatePublished - Oct 2011


  • Acute heart failure
  • Clinical trials
  • Phase 2

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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