A road map for those who don't know JAK-STAT

David S. Aaronson, Curt M. Horvath*

*Corresponding author for this work

Research output: Contribution to journalShort survey

849 Citations (Scopus)

Abstract

The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transmits information received from extracellular polypeptide signals, through transmembrane receptors, directly to target gene promoters in the nucleus, providing a mechanism for transcriptional regulation without second messengers. Evolutionarily conserved in eukaryotic organisms from slime molds to humans, JAK-STAT signaling appears to be an early adaptation to facilitate intercellular communication that has co-evolved with myriad cellular signaling events. This co-evolution has given rise to highly adapted, ligand-specific signaling pathways that control gene expression. In addition, the JAK-STAT signaling pathways are regulated by a vast array of intrinsic and environmental stimuli, which can add plasticity to the response of a cell or tissue.

Original languageEnglish (US)
Pages (from-to)1653-1655
Number of pages3
JournalScience
Volume296
Issue number5573
DOIs
StatePublished - May 31 2002

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Janus Kinases
Transducers
Second Messenger Systems
Fungi
Ligands
Gene Expression
Peptides
Genes

ASJC Scopus subject areas

  • General

Cite this

Aaronson, David S. ; Horvath, Curt M. / A road map for those who don't know JAK-STAT. In: Science. 2002 ; Vol. 296, No. 5573. pp. 1653-1655.
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A road map for those who don't know JAK-STAT. / Aaronson, David S.; Horvath, Curt M.

In: Science, Vol. 296, No. 5573, 31.05.2002, p. 1653-1655.

Research output: Contribution to journalShort survey

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