A role for DNA sequence in controlling the spatial organization of the genome

Sara Ahmed, Jason H. Brickner

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Recruitment of genes to the nuclear periphery upon transcriptional activation is a common phenomenon in Saccharomyces cerevisiae. We have recently identified DNA elements called gene recruitment sequences (GRSs) in the promoters of genes that are recruited to the nuclear periphery. These elements are necessary for peripheral targeting of genes. GRSs also function as DNA zip codes: they are sufficient to target an ectopic locus to the nuclear periphery. Targeting promotes full transcription and involves the interaction of promoters with the Nuclear Pore Complex (NPC). GRSs are widespread across the yeast genome, and are enriched in the promoters of genes induced by protein folding stress. Here, we place these observations in the context of the more global topic of genome organization and speculate about how the position of genes impacts their expression.

Original languageEnglish (US)
Article number12637
JournalNucleus
Volume1
Issue number5
DOIs
StatePublished - 2010

Keywords

  • DNA zip code
  • Gene positioning
  • Nuclear periphery
  • Saccharomyces cerevisiae
  • Transcription

ASJC Scopus subject areas

  • Cell Biology

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