A role for the mannose-sensitive hemagglutinin in biofilm formation by Vibrio cholerae El Tor

Paula I. Watnick, Karla Jean Fullner, Roberto Kolter*

*Corresponding author for this work

Research output: Contribution to journalArticle

206 Scopus citations

Abstract

While much has been learned regarding the genetic basis of host-pathogen interactions, less is known about the molecular basis of a pathogen's survival in the environment. Biofilm formation on abiotic surfaces represents a survival strategy utilized by many microbes. Here it is shown that Vibrio cholerae El Tor does not use the virulence-associated toxin-coregulated pilus to form biofilms on borosilicate but rather uses the mannose-sensitive hemagglutinin (MSHA) pilus, which plays no role in pathogenicity. In contrast, attachment of V. cholerae to chitin is shown to be independent of the MSHA pilus, suggesting divergent pathways for biofilm formation on nutritive and nonnutritive abiotic surfaces.

Original languageEnglish (US)
Pages (from-to)3606-3609
Number of pages4
JournalJournal of bacteriology
Volume181
Issue number11
DOIs
StatePublished - Jun 1999

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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