A secoiridoid with quinone reductase inducing activity from Cortex fraxini

Lijun Wang, Fang Sun, Xiaoyu Zhang, Zhongjun Ma*, Lin Cheng

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

A new secoiridoid named chinensisol (1) along with twenty known compounds were isolated from the 95% ethanol extract of Cortex fraxini. Their structures were elucidated on the basis of NMR, MS, IR and UV spectral evidences. The quinone reductase (QR) inducing activities of the compounds were evaluated and the results showed that compounds 1, 9 and 14 had moderate QR inducing activities with CD values (concentration required to double the specific activity of QR) of 72.4 ± 7.7, 34.3 ± 3.3 and 42.0 ± 0.4 μM respectively.

Original languageEnglish (US)
Pages (from-to)834-837
Number of pages4
JournalFitoterapia
Volume81
Issue number7
DOIs
StatePublished - Oct 2010
Externally publishedYes

Keywords

  • Cortex fraxni
  • Quinone reductase
  • Secoiridoid

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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