A secoiridoid with quinone reductase inducing activity from Cortex fraxini

Lijun Wang; Fang Sun; Xiaoyu Zhang; Zhongjun Ma; Lin Cheng

doi:10.1016/j.fitote.2010.05.003

A secoiridoid with quinone reductase inducing activity from Cortex fraxini

Lijun Wang, Fang Sun, Xiaoyu Zhang, Zhongjun Ma^*, Lin Cheng

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

A new secoiridoid named chinensisol (1) along with twenty known compounds were isolated from the 95% ethanol extract of Cortex fraxini. Their structures were elucidated on the basis of NMR, MS, IR and UV spectral evidences. The quinone reductase (QR) inducing activities of the compounds were evaluated and the results showed that compounds 1, 9 and 14 had moderate QR inducing activities with CD values (concentration required to double the specific activity of QR) of 72.4 ± 7.7, 34.3 ± 3.3 and 42.0 ± 0.4 μM respectively.

Original language	English (US)
Pages (from-to)	834-837
Number of pages	4
Journal	Fitoterapia
Volume	81
Issue number	7
DOIs	https://doi.org/10.1016/j.fitote.2010.05.003
State	Published - Oct 2010
Externally published	Yes

Keywords

Cortex fraxni
Quinone reductase
Secoiridoid

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1016/j.fitote.2010.05.003

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title = "A secoiridoid with quinone reductase inducing activity from Cortex fraxini",

abstract = "A new secoiridoid named chinensisol (1) along with twenty known compounds were isolated from the 95% ethanol extract of Cortex fraxini. Their structures were elucidated on the basis of NMR, MS, IR and UV spectral evidences. The quinone reductase (QR) inducing activities of the compounds were evaluated and the results showed that compounds 1, 9 and 14 had moderate QR inducing activities with CD values (concentration required to double the specific activity of QR) of 72.4 ± 7.7, 34.3 ± 3.3 and 42.0 ± 0.4 μM respectively.",

keywords = "Cortex fraxni, Quinone reductase, Secoiridoid",

author = "Lijun Wang and Fang Sun and Xiaoyu Zhang and Zhongjun Ma and Lin Cheng",

note = "Funding Information: The work was financially supported by Zhejiang Key Science & Technological Program ( 2009C13028 ).",

year = "2010",

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doi = "10.1016/j.fitote.2010.05.003",

language = "English (US)",

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T1 - A secoiridoid with quinone reductase inducing activity from Cortex fraxini

AU - Wang, Lijun

AU - Sun, Fang

AU - Zhang, Xiaoyu

AU - Ma, Zhongjun

AU - Cheng, Lin

N1 - Funding Information: The work was financially supported by Zhejiang Key Science & Technological Program ( 2009C13028 ).

PY - 2010/10

Y1 - 2010/10

N2 - A new secoiridoid named chinensisol (1) along with twenty known compounds were isolated from the 95% ethanol extract of Cortex fraxini. Their structures were elucidated on the basis of NMR, MS, IR and UV spectral evidences. The quinone reductase (QR) inducing activities of the compounds were evaluated and the results showed that compounds 1, 9 and 14 had moderate QR inducing activities with CD values (concentration required to double the specific activity of QR) of 72.4 ± 7.7, 34.3 ± 3.3 and 42.0 ± 0.4 μM respectively.

AB - A new secoiridoid named chinensisol (1) along with twenty known compounds were isolated from the 95% ethanol extract of Cortex fraxini. Their structures were elucidated on the basis of NMR, MS, IR and UV spectral evidences. The quinone reductase (QR) inducing activities of the compounds were evaluated and the results showed that compounds 1, 9 and 14 had moderate QR inducing activities with CD values (concentration required to double the specific activity of QR) of 72.4 ± 7.7, 34.3 ± 3.3 and 42.0 ± 0.4 μM respectively.

KW - Cortex fraxni

KW - Quinone reductase

KW - Secoiridoid

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JO - Fitoterapia

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IS - 7

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A secoiridoid with quinone reductase inducing activity from Cortex fraxini

Abstract

Keywords

ASJC Scopus subject areas

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