A Second Heart Field-Derived Vasculogenic Niche Contributes to Cardiac Lymphatics

Ghislaine Lioux, Xiaolei Liu, Susana Temiño, Michael Oxendine, Estefanía Ayala, Sagrario Ortega, Robert G. Kelly, Guillermo Oliver, Miguel Torres*

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Lioux et al., identify a population of coronary lymphatics that originates from non-venous cells of the Second Heart Field and contributes to about 50% of lymphatic endothelial cells of the ventral heart. This population is nonetheless essential for ventral heart lymphatics development, highlighting the functional relevance of coronary lymphatics heterogeneity.

Original languageEnglish (US)
Pages (from-to)350-363.e6
JournalDevelopmental Cell
Volume52
Issue number3
DOIs
StatePublished - Feb 10 2020

Keywords

  • Islet1Cre
  • clonal analysis
  • coronary vasculature
  • epicardium
  • lymphatic endothelium
  • mesothelium
  • pericardium
  • retinoic acid
  • vasculogenesis

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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    Lioux, G., Liu, X., Temiño, S., Oxendine, M., Ayala, E., Ortega, S., Kelly, R. G., Oliver, G., & Torres, M. (2020). A Second Heart Field-Derived Vasculogenic Niche Contributes to Cardiac Lymphatics. Developmental Cell, 52(3), 350-363.e6. https://doi.org/10.1016/j.devcel.2019.12.006