A Second Heart Field-Derived Vasculogenic Niche Contributes to Cardiac Lymphatics

Ghislaine Lioux, Xiaolei Liu, Susana Temiño, Michael Oxendine, Estefanía Ayala, Sagrario Ortega, Robert G. Kelly, Guillermo Oliver, Miguel Torres*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Lioux et al., identify a population of coronary lymphatics that originates from non-venous cells of the Second Heart Field and contributes to about 50% of lymphatic endothelial cells of the ventral heart. This population is nonetheless essential for ventral heart lymphatics development, highlighting the functional relevance of coronary lymphatics heterogeneity.

Original languageEnglish (US)
Pages (from-to)350-363.e6
JournalDevelopmental Cell
Issue number3
StatePublished - Feb 10 2020


  • Islet1Cre
  • clonal analysis
  • coronary vasculature
  • epicardium
  • lymphatic endothelium
  • mesothelium
  • pericardium
  • retinoic acid
  • vasculogenesis

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • Molecular Biology
  • Cell Biology
  • Developmental Biology


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