Abstract
Lioux et al., identify a population of coronary lymphatics that originates from non-venous cells of the Second Heart Field and contributes to about 50% of lymphatic endothelial cells of the ventral heart. This population is nonetheless essential for ventral heart lymphatics development, highlighting the functional relevance of coronary lymphatics heterogeneity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 350-363.e6 |
| Journal | Developmental Cell |
| Volume | 52 |
| Issue number | 3 |
| DOIs | |
| State | Published - Feb 10 2020 |
Funding
We thank Cristina Villa del Campo, Ester de la Cruz, and other members of the Torres group for stimulating discussions and suggestions. We thank members of the Microscopy, Genomics, Bioinformatics, Transgenesis, and Animal Facility CNIC units for excellent support. This work was supported by grants PGC2018-096486-B-I00 and RD16/0011/0019 (ISCIII) from the Spanish Ministry of Science, Innovation, and Universities and grant S2017/BMD3875 from the Comunidad de Madrid to M.T., grant ITN-CARDIONET-ref. 289600 from EU to G.L., and by grant BFU2015-71376-R to S.O. The CNIC is supported by the Ministerio de Ciencia, Innovación y Universidades, and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence ( SEV-2015-0505 ). We thank Cristina Villa del Campo, Ester de la Cruz, and other members of the Torres group for stimulating discussions and suggestions. We thank members of the Microscopy, Genomics, Bioinformatics, Transgenesis, and Animal Facility CNIC units for excellent support. This work was supported by grants PGC2018-096486-B-I00 and RD16/0011/0019 (ISCIII) from the Spanish Ministry of Science, Innovation, and Universities and grant S2017/BMD3875 from the Comunidad de Madrid to M.T. grant ITN-CARDIONET-ref.289600 from EU to G.L. and by grant BFU2015-71376-R to S.O. The CNIC is supported by the Ministerio de Ciencia, Innovaci?n y Universidades, and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505). G.L. designed, performed, and analyzed experiments, mounted figures, and wrote the manuscript; X.L. performed and analyzed experiments; S.T. provided technical support, M.O. performed and analyzed experiments; E.A. and S.O. provided mouse lines and performed experimental procedures; R.G.K. provided mouse lines and resources and contributed to data interpretation and manuscript writing; G.O. contributed mouse lines and resources and contributed to data interpretation and manuscript writing; M.T. supervised the work, designed and analyzed experiments, mounted figures, and wrote the manuscript. The authors declare no competing interests.
Keywords
- Islet1Cre
- clonal analysis
- coronary vasculature
- epicardium
- lymphatic endothelium
- mesothelium
- pericardium
- retinoic acid
- vasculogenesis
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
- Molecular Biology
- Cell Biology
- Developmental Biology
