A second leiomyosarcoma in the urinary bladder of a child with a history of retinoblastoma 12 years following partial cystectomy

Benjamin Brucker*, Linda Ernst, Anna Meadows, Stephen Zderic

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

This case describes a twin with bilateral retinoblastoma who developed leiomyosarcoma of the bladder at age 17 and again at 39. At 17-years of age she was diagnosed with a leiomyosarcoma of the bladder after presenting with recurrent urinary tract infections, hematuria, and dysuria. She was treated with partial cystectomy. After a 12-year disease-free interval, she was diagnosed with a second leiomyosarcoma of the bladder. This case supports the relationship between the genetic form of retinoblastoma and leiomyosarcoma and illustrates the necessity for extensive follow-up and well-defined treatment of secondary neoplasms.

Original languageEnglish (US)
Pages (from-to)811-814
Number of pages4
JournalPediatric Blood and Cancer
Volume46
Issue number7
DOIs
StatePublished - Jun 1 2006

Keywords

  • Bladder neoplasm
  • Cyclophosphamide
  • Leiomyosarcoma
  • Retinoblastoma
  • Secondary neoplasm

ASJC Scopus subject areas

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology

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