A sequential treatment algorithm for infants with stage 4s neuroblastoma and massive hepatomegaly

Michael Weintraub*, Elisha Waldman, Benjamin Koplewitz, Allan I. Bloom, Eitan Gross, Arnold I. Freeman, Shoshana Revel-Vilk

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Infants with 4s neuroblastoma (NB) and massive hepatomegaly have a guarded prognosis and mortality approaches 30%. We report on eight patients with 4s NB and massive hepatomegaly treated with multiple modalities. One patient had spontaneous tumor regression. Three patients had progressive disease and responded to chemotherapy. Four patients progressed despite intravenous chemotherapy, of whom two died, and two were salvaged with hepatic intra-arterial chemoembolization. Treatment of infants with stage 4s NB with massive hepatomegaly should be individualized based on disease course. A sequential approach with observation, intravenous chemotherapy, and intra-arterial chemoembolization, may improve the outcome of these infants.

Original languageEnglish (US)
Pages (from-to)182-184
Number of pages3
JournalPediatric Blood and Cancer
Volume59
Issue number1
DOIs
StatePublished - Jul 15 2012

Keywords

  • Hepatic neuroblastoma
  • Neonatal neuroblastoma
  • Neuroblastoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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