Abstract
Combining biological and small-molecule catalysts under a chemoenzymatic manifold presents a series of significant advantages to the synthetic community. We report herein the successful development of a two-step/single flask synthesis of γ-lactones through the merger of Umpolung catalysis with a ketoreductase-catalyzed dynamic kinetic resolution, reduction, and cyclization. This combined approach delivers highly enantio- and diastereoenriched heterocycles and demonstrates the feasibility of integrating NHC catalysis with enzymatic processes.
Original language | English (US) |
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Pages (from-to) | 5794-5798 |
Number of pages | 5 |
Journal | Chemistry - A European Journal |
Volume | 26 |
Issue number | 26 |
DOIs | |
State | Published - May 7 2020 |
Keywords
- N-heterocyclic carbene catalysis
- chemoenzymatic catalysis
- ketoreductase enzyme
- photoredox catalysis
- sequential catalysis
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry
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CCDC 1973184: Experimental Crystal Structure Determination
Maskeri, M. A. (Contributor), Schrader, M. L. (Contributor) & Scheidt, K. A. (Contributor), Cambridge Crystallographic Data Centre, 2020
DOI: 10.5517/ccdc.csd.cc24783s, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc24783s&sid=DataCite
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