@article{f65723de0f0f4eb7a155b862f4d35b0e,
title = "A Sequential Umpolung/Enzymatic Dynamic Kinetic Resolution Strategy for the Synthesis of γ-Lactones",
abstract = "Combining biological and small-molecule catalysts under a chemoenzymatic manifold presents a series of significant advantages to the synthetic community. We report herein the successful development of a two-step/single flask synthesis of γ-lactones through the merger of Umpolung catalysis with a ketoreductase-catalyzed dynamic kinetic resolution, reduction, and cyclization. This combined approach delivers highly enantio- and diastereoenriched heterocycles and demonstrates the feasibility of integrating NHC catalysis with enzymatic processes.",
keywords = "N-heterocyclic carbene catalysis, chemoenzymatic catalysis, ketoreductase enzyme, photoredox catalysis, sequential catalysis",
author = "Maskeri, {Mark A.} and Schrader, {Malte L.} and Scheidt, {Karl A.}",
note = "Funding Information: We thank Northwestern and the National Institute of General Medical Sciences (GM073072 and GM131431) for support of this work. The authors thank Keegan Fitzpatrick and Charlotte Stern (NU) for X-ray crystallography assistance, Ada Kwong (NU) for high-resolution mass spectrometry assistance, and Dr. Adam Csakai for helpful early discussions. Funding Information: We thank Northwestern and the National Institute of General Medical Sciences (GM073072 and GM131431) for support of this work. The authors thank Keegan Fitzpatrick and Charlotte Stern (NU) for X‐ray crystallography assistance, Ada Kwong (NU) for high‐resolution mass spectrometry assistance, and Dr. Adam Csakai for helpful early discussions. Publisher Copyright: {\textcopyright} 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2020",
month = may,
day = "7",
doi = "10.1002/chem.202000747",
language = "English (US)",
volume = "26",
pages = "5794--5798",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "Wiley-VCH Verlag",
number = "26",
}