A set of functionally-defined brain regions with improved representation of the subcortex and cerebellum

Benjamin A. Seitzman*, Caterina Gratton, Scott Marek, Ryan V. Raut, Nico U.F. Dosenbach, Bradley L. Schlaggar, Steven E. Petersen, Deanna J. Greene

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

146 Scopus citations

Abstract

An important aspect of network-based analysis is robust node definition. This issue is critical for functional brain network analyses, as poor node choice can lead to spurious findings and misleading inferences about functional brain organization. Two sets of functional brain nodes from our group are well represented in the literature: (1) 264 volumetric regions of interest (ROIs) reported in Power et al., 2011, and (2) 333 cortical surface parcels reported in Gordon et al., 2016. However, subcortical and cerebellar structures are either incompletely captured or missing from these ROI sets. Therefore, properties of functional network organization involving the subcortex and cerebellum may be underappreciated thus far. Here, we apply a winner-take-all partitioning method to resting-state fMRI data to generate novel functionally-constrained ROIs in the thalamus, basal ganglia, amygdala, hippocampus, and cerebellum. We validate these ROIs in three datasets using several criteria, including agreement with existing literature and anatomical atlases. Further, we demonstrate that combining these ROIs with established cortical ROIs recapitulates and extends previously described functional network organization. This new set of ROIs is made publicly available for general use, including a full list of MNI coordinates and functional network labels.

Original languageEnglish (US)
Article number116290
JournalNeuroimage
Volume206
DOIs
StatePublished - Feb 1 2020

Funding

This work was supported by National Institutes of Health grants T32 NS073547 ( BAS ), F32 NS092290 ( CG ), T32 MH10001902 ( SM ), K23 NS088590 ( NUFD ), UL1 TR000448 ( NUFD ), R01 NS32979 ( SEP ), R01 NS06424 ( SEP ), and K01 MH104592 (DJG); the National Science Foundation grant DGE-1745038 (RVR); the Jacobs Foundation grant 2016121703 (NUFD); the Child Neurology Foundation (NUFD); the Mallinckrodt Institute of Radiology grant 14–011 (NUFD); the Hope Center for Neurological Disorders (NUFD, BLS , SEP ); the James S. McDonnell Foundation Collaborative Activity Award ( SEP ); the McDonnell Center for Systems Neuroscience (NUFD, BLS , DJG); and, the Tourette Association of America (DJG).

Keywords

  • Cerebellum
  • Functional connectivity
  • Networks
  • Resting-state
  • Subcortical

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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