A signaling pathway governing early thymocyte maturation

Steven J. Anderson; Roger M. Perlmutter

doi:10.1016/0167-5699(95)80096-4

A signaling pathway governing early thymocyte maturation

Steven J. Anderson, Roger M. Perlmutter

Microbiology-Immunology

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

Recent evidence supports the view that p56^lck, a non-receptor protein tyrosine kinase, serves as the signaling element that 'senses' synthesis of a functional T-cell receptor β chain, thereby promoting thymocyte maturation. Here, Steven Anderson and Roger Perlmutter review current data, and outline the features of this developmental program.

Original language	English (US)
Pages (from-to)	99-105
Number of pages	7
Journal	Immunology Today
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/0167-5699(95)80096-4
State	Published - 1995

ASJC Scopus subject areas

Immunology

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10.1016/0167-5699(95)80096-4

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title = "A signaling pathway governing early thymocyte maturation",

abstract = "Recent evidence supports the view that p56lck, a non-receptor protein tyrosine kinase, serves as the signaling element that 'senses' synthesis of a functional T-cell receptor β chain, thereby promoting thymocyte maturation. Here, Steven Anderson and Roger Perlmutter review current data, and outline the features of this developmental program.",

author = "Anderson, {Steven J.} and Perlmutter, {Roger M.}",

note = "Funding Information: Work described in this article was supported in part by a grant from the NIH (CA-45682). We thank Kathi Prewitt for secretarial assistance, and our colleagues for helpful discussions. RMP is an Investigator of the Howard Hughes Medical Institute.",

year = "1995",

doi = "10.1016/0167-5699(95)80096-4",

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AU - Anderson, Steven J.

AU - Perlmutter, Roger M.

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PY - 1995

Y1 - 1995

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AB - Recent evidence supports the view that p56lck, a non-receptor protein tyrosine kinase, serves as the signaling element that 'senses' synthesis of a functional T-cell receptor β chain, thereby promoting thymocyte maturation. Here, Steven Anderson and Roger Perlmutter review current data, and outline the features of this developmental program.

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A signaling pathway governing early thymocyte maturation

Abstract

ASJC Scopus subject areas

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