A signaling pathway governing early thymocyte maturation

Steven J. Anderson, Roger M. Perlmutter

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


Recent evidence supports the view that p56lck, a non-receptor protein tyrosine kinase, serves as the signaling element that 'senses' synthesis of a functional T-cell receptor β chain, thereby promoting thymocyte maturation. Here, Steven Anderson and Roger Perlmutter review current data, and outline the features of this developmental program.

Original languageEnglish (US)
Pages (from-to)99-105
Number of pages7
JournalImmunology Today
Issue number2
StatePublished - 1995

ASJC Scopus subject areas

  • Immunology


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