A simple and versatile method for the synthesis of acetals from aldehydes and ketones using bismuth triflate

Nicholas M. Leonard, Matthew C. Oswald, Derek A. Freiberg, Bryce A. Nattier, Russell C. Smith, Ram S. Mohan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

146 Scopus citations

Abstract

Acetals are obtained in good yields by treatment of aldehydes and ketones with trialkyl orthoformate and the corresponding alcohol in the presence of 0.1 mol % Bi(OTf)3·4H2O. A simple procedure for the formation of acetals of diaryl ketones has also been developed. The conversion of carbonyl compounds to the corresponding 1,3-dioxolane using ethylene glycol is also catalyzed by Bi(OTf)3· 4H2O (1 mol %). Two methods, both of which avoid the use of benzene, have been developed.

Original languageEnglish (US)
Pages (from-to)5202-5207
Number of pages6
JournalJournal of Organic Chemistry
Volume67
Issue number15
DOIs
StatePublished - Jul 26 2002

ASJC Scopus subject areas

  • Organic Chemistry

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