A Simple Mechanical Model for Synthetic Catch Bonds

Kerim C. Dansuk, Sinan Keten*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Dansuk and Keten have demonstrated that a simple mechanical design based on a tweezer-like mechanism can exhibit catch bond characteristics under thermal excitations. By introducing a switch design with broader energy landscape than the ligand binding site landscape, they achieve force-dependent kinetics that prolongs ligand lifetime through formation of secondary interactions. This serial arrangement of a soft conformational switch with a stiff ligand interaction results in catch bonds. The force versus lifetime curves are tunable by changing these design parameters.

Original languageEnglish (US)
Pages (from-to)911-925
Number of pages15
JournalMatter
Volume1
Issue number4
DOIs
StatePublished - Oct 2 2019

Keywords

  • MAP 3: Understanding
  • adhesins
  • biomimetics
  • catch bond
  • nanocomposites
  • structure-function relationship
  • unbinding kinetics

ASJC Scopus subject areas

  • Materials Science(all)

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