A simple method for the purification of factor VIII (antihemophilic factor) employing snake venom

David Green*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

A simple method has been described for the preparation of small amounts of highly purified factor VIII (antihemophilic factor). Cryoprecipitate is clotted with a purified extract of snake venom (Arvin), and the resultant product is filtered through Sepharose. The mean specific activity of factor VIII prepared by this method is 124 U. per milligram of protein, representing an 8,665-fold purification of the factor.

Original languageEnglish (US)
Pages (from-to)153-158
Number of pages6
JournalThe Journal of Laboratory and Clinical Medicine
Volume77
Issue number1
StatePublished - Jan 1 1971

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)

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