A simple sheath-flow microfluidic device for micro/nanomanufacturing: Fabrication of hydrodynamically shaped polymer fibers

Abel L. Thangawng, Peter B. Howell, Jeffrey J. Richards, Jeffrey S. Erickson, Frances S. Ligler

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

A simple sheath flow microfluidic device is used to fabricate polymer micro/nanofibers that have precisely controlled shapes and sizes. Poly(methylmethacrylate) (PMMA) was used as the model polymer for these experiments. The sheath-flow device uses straight diagonal and chevron-shaped grooves integrated in the top and bottom walls of the flow channel to move sheath fluid completely around the polymer stream. Portions of the sheath stream are deflected in such a way as to define the cross-sectional shape of the polymer core. The flow-rate ratio between the sheath and core solution determines the fiber diameter. Round PMMA fibers with a diameter as small as 300 nm and flattened fibers with a submicron thickness are demonstrated.

Original languageEnglish (US)
Pages (from-to)3126-3130
Number of pages5
JournalLab on a Chip
Volume9
Issue number21
DOIs
StatePublished - Jan 1 2009

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

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