A simple synthetic replicator amplifies itself from a dynamic reagent pool

Jan W. Sadownik, Douglas Philp

Research output: Contribution to journalArticlepeer-review

114 Scopus citations


(Figure Presented) The fate of a dynamic combinatorial library is determined by coupling the exchange processes to a synthetic replicator. The replicating template is capable of exploiting and dominating the exchanging pool of reagents in order to amplify its own formation at the expense of other species (see picture) through the nonlinear kinetics inherent in minimal replication.

Original languageEnglish (US)
Pages (from-to)9965-9970
Number of pages6
JournalAngewandte Chemie - International Edition
Issue number51
StatePublished - Dec 8 2008


  • Dynamic covalent chemistry
  • Molecular recognition
  • Reaction networks
  • Self-replication
  • Systems chemistry

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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