A simple synthetic replicator amplifies itself from a dynamic reagent pool

Jan W. Sadownik; Douglas Philp

doi:10.1002/anie.200804223

A simple synthetic replicator amplifies itself from a dynamic reagent pool

Jan W. Sadownik, Douglas Philp

Chemistry

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Abstract

(Figure Presented) The fate of a dynamic combinatorial library is determined by coupling the exchange processes to a synthetic replicator. The replicating template is capable of exploiting and dominating the exchanging pool of reagents in order to amplify its own formation at the expense of other species (see picture) through the nonlinear kinetics inherent in minimal replication.

Original language	English (US)
Pages (from-to)	9965-9970
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	51
DOIs	https://doi.org/10.1002/anie.200804223
State	Published - Dec 8 2008

Keywords

Dynamic covalent chemistry
Molecular recognition
Reaction networks
Self-replication
Systems chemistry

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200804223

Cite this

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abstract = "(Figure Presented) The fate of a dynamic combinatorial library is determined by coupling the exchange processes to a synthetic replicator. The replicating template is capable of exploiting and dominating the exchanging pool of reagents in order to amplify its own formation at the expense of other species (see picture) through the nonlinear kinetics inherent in minimal replication.",

keywords = "Dynamic covalent chemistry, Molecular recognition, Reaction networks, Self-replication, Systems chemistry",

author = "Sadownik, {Jan W.} and Douglas Philp",

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AB - (Figure Presented) The fate of a dynamic combinatorial library is determined by coupling the exchange processes to a synthetic replicator. The replicating template is capable of exploiting and dominating the exchanging pool of reagents in order to amplify its own formation at the expense of other species (see picture) through the nonlinear kinetics inherent in minimal replication.

KW - Dynamic covalent chemistry

KW - Molecular recognition

KW - Reaction networks

KW - Self-replication

KW - Systems chemistry

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A simple synthetic replicator amplifies itself from a dynamic reagent pool

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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