A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal plate

Hua Shun Li, Christopher Tierney, Leng Wen, Jane Y. Wu, Yi Rao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

227 Scopus citations

Abstract

Two bilaterally symmetric eyes arise from the anterior neural plate in vertebrate embryos. An interesting question is whether both eyes share a common developmental origin or they originate separately. We report here that the expression pattern of a new gene ET reveals that there is a single retina field which resolves into two separate primordia, a suggestion supported by the expression pattern of the Xenopus Pax-6 gene. Lineage tracing experiments demonstrate that retina field resolution is not due to migration of cells in the median region to the lateral parts of the field, Removal of the prechordal mesoderm led to formation of a single retina both in chick embryos and in Xenopus explants. Transplantation experiments in chick embryos indicate that the prechordal plate is able to suppress Pax-6 expression, Our results provide direct evidence for the existence of a single retina field, indicate that the retina field is resolved by suppression of retina formation in the median region of the field, and demonstrate that the prechordal plate plays a primary signaling role in retina field resolution.

Original languageEnglish (US)
Pages (from-to)603-615
Number of pages13
JournalDevelopment
Volume124
Issue number3
StatePublished - Feb 1997

Keywords

  • Bilateral symmetry
  • Eye development
  • Prechordal mesoderm
  • Retina field

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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