A small catalytic oligoribonucleotide

Olke C. Uhlenbeck*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

836 Scopus citations


A 19-nucleotide RNA fragment can cause rapid, highly specific cleavage of a 24-nucleotide RNA fragment under physiological conditions. Because each 19-mer can participate in many cleavage reactions, this molecule has all the properties associated with an RNA enzyme.

Original languageEnglish (US)
Pages (from-to)596-600
Number of pages5
Issue number6131
StatePublished - 1988

ASJC Scopus subject areas

  • General

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