A small-molecule agonist of the Wnt signaling pathway

Jun Liu; Xu Wu; Brian Mitchell; Chris Kintner; Sheng Ding; Peter G. Schultz

doi:10.1002/anie.200462552

A small-molecule agonist of the Wnt signaling pathway

Jun Liu^*, Xu Wu, Brian Mitchell, Chris Kintner, Sheng Ding, Peter G. Schultz

^*Corresponding author for this work

Cell & Developmental Biology

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Abstract

(Chemical Equation Presented) A new tool for developmental biology: A screen of combinatorial chemical libraries identified the 2-amino-4,6- disubstituted pyrimidine 1 as a dose-dependent agonist of Wnt signaling. Tadpoles that developed from embryos treated with 1 had substantial head defects (see right-hand image; left = control). Compound 1 appears to mimic the effects of a Wnt ligand in a Xenopus model and may be a useful tool in the study of physiological processes that involve the Wnt pathway.

Original language	English (US)
Pages (from-to)	1987-1990
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	44
Issue number	13
DOIs	https://doi.org/10.1002/anie.200462552
State	Published - Mar 18 2005

Keywords

Cellular adhesion
Gene expression
High-throughput screening
Pyrimidines
Signal transduction

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200462552

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AB - (Chemical Equation Presented) A new tool for developmental biology: A screen of combinatorial chemical libraries identified the 2-amino-4,6- disubstituted pyrimidine 1 as a dose-dependent agonist of Wnt signaling. Tadpoles that developed from embryos treated with 1 had substantial head defects (see right-hand image; left = control). Compound 1 appears to mimic the effects of a Wnt ligand in a Xenopus model and may be a useful tool in the study of physiological processes that involve the Wnt pathway.

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KW - Signal transduction

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A small-molecule agonist of the Wnt signaling pathway

Abstract

Keywords

ASJC Scopus subject areas

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