A small-molecule agonist of the Wnt signaling pathway

Jun Liu*, Xu Wu, Brian Mitchell, Chris Kintner, Sheng Ding, Peter G. Schultz

*Corresponding author for this work

Research output: Contribution to journalArticle

85 Scopus citations

Abstract

(Chemical Equation Presented) A new tool for developmental biology: A screen of combinatorial chemical libraries identified the 2-amino-4,6- disubstituted pyrimidine 1 as a dose-dependent agonist of Wnt signaling. Tadpoles that developed from embryos treated with 1 had substantial head defects (see right-hand image; left = control). Compound 1 appears to mimic the effects of a Wnt ligand in a Xenopus model and may be a useful tool in the study of physiological processes that involve the Wnt pathway.

Original languageEnglish (US)
Pages (from-to)1987-1990
Number of pages4
JournalAngewandte Chemie - International Edition
Volume44
Issue number13
DOIs
StatePublished - Mar 18 2005

Keywords

  • Cellular adhesion
  • Gene expression
  • High-throughput screening
  • Pyrimidines
  • Signal transduction

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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