A Small-Molecule Approach to Restore a Slow-Oxidative Phenotype and Defective CaMKIIβ Signaling in Limb Girdle Muscular Dystrophy

Jian Liu, Jesus Campagna, Varghese John, Robert Damoiseaux, Ekaterina Mokhonova, Diana Becerra, Huan Meng, Elizabeth M. McNally, April D. Pyle, Irina Kramerova*, Melissa J. Spencer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Failure to properly induce the signaling pathways that are activated by exercise and which promote the slow-oxidative gene expression program in muscle leads to limb girdle muscular dystrophy. Liu et al. report that a small molecule could activate these pathways and restore both the defective signaling and transcriptional patterns needed to reverse the muscle phenotype.

Original languageEnglish (US)
Article number100122
JournalCell Reports Medicine
Volume1
Issue number7
DOIs
StatePublished - Oct 20 2020

Keywords

  • CaMK signaling
  • calcium calmodulin kinase
  • calpain
  • calpainopathy
  • exercise
  • fiber type
  • high-throughput screen
  • limb girdle muscular dystrophy
  • mitochondria
  • muscle

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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