Failure to properly induce the signaling pathways that are activated by exercise and which promote the slow-oxidative gene expression program in muscle leads to limb girdle muscular dystrophy. Liu et al. report that a small molecule could activate these pathways and restore both the defective signaling and transcriptional patterns needed to reverse the muscle phenotype.
- CaMK signaling
- calcium calmodulin kinase
- fiber type
- high-throughput screen
- limb girdle muscular dystrophy
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)